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Oral function in patients with myasthenia gravis

Myasthenia Gravis (MG) is characterised by muscle weakness and increased fatigability. The aim of this pilot study was to investigate if patients with MG demonstrate different functional chewing patterns and report more complaints related to mastication as compared with healthy controls. Twelve pati...

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Autores principales: Donskov, Agnete Overgaard, Shimada, Akiko, Vinge, Lotte, Svensson, Peter, Andersen, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253106/
https://www.ncbi.nlm.nih.gov/pubmed/34249511
http://dx.doi.org/10.7717/peerj.11680
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author Donskov, Agnete Overgaard
Shimada, Akiko
Vinge, Lotte
Svensson, Peter
Andersen, Henning
author_facet Donskov, Agnete Overgaard
Shimada, Akiko
Vinge, Lotte
Svensson, Peter
Andersen, Henning
author_sort Donskov, Agnete Overgaard
collection PubMed
description Myasthenia Gravis (MG) is characterised by muscle weakness and increased fatigability. The aim of this pilot study was to investigate if patients with MG demonstrate different functional chewing patterns and report more complaints related to mastication as compared with healthy controls. Twelve patients (median 60 years Q1–Q3: 46–70) with generalised MG and nine healthy controls (median 57 years Q1–Q3: 55–63) participated. All participants underwent dental and oral examination and were asked to fill in a questionnaire concerning oral health. Static maximum bite force was measured with a bite force transducer, electromyography in the masseter, temporalis, and suprahyoid muscles were recorded, and jaw movement was tracked, during a 5-minute gum chewing test. The patients had more oral complaints (oral health impact profile total score 22.6 vs 7.5 P < 0.01) and had lower peak bite force than controls (18.8kgf (11.1;26.4) (95% CI) vs 29.5 kgf (21.6; 37.4) (P = 0.04)). In contrast, fatigability of the masticatory muscles, as defined by number of chewing cycles during the gum-chewing test, did not differ between patients and controls (P = 0.10). In conclusion, patients had more oral complaints and lower bite force than controls, but did not show significantly different functional chewing patterns. Future studies should aim at integrating measurement of peak force into functional tests. Attention should be given to oral complaints of patients with MG.
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spelling pubmed-82531062021-07-08 Oral function in patients with myasthenia gravis Donskov, Agnete Overgaard Shimada, Akiko Vinge, Lotte Svensson, Peter Andersen, Henning PeerJ Dentistry Myasthenia Gravis (MG) is characterised by muscle weakness and increased fatigability. The aim of this pilot study was to investigate if patients with MG demonstrate different functional chewing patterns and report more complaints related to mastication as compared with healthy controls. Twelve patients (median 60 years Q1–Q3: 46–70) with generalised MG and nine healthy controls (median 57 years Q1–Q3: 55–63) participated. All participants underwent dental and oral examination and were asked to fill in a questionnaire concerning oral health. Static maximum bite force was measured with a bite force transducer, electromyography in the masseter, temporalis, and suprahyoid muscles were recorded, and jaw movement was tracked, during a 5-minute gum chewing test. The patients had more oral complaints (oral health impact profile total score 22.6 vs 7.5 P < 0.01) and had lower peak bite force than controls (18.8kgf (11.1;26.4) (95% CI) vs 29.5 kgf (21.6; 37.4) (P = 0.04)). In contrast, fatigability of the masticatory muscles, as defined by number of chewing cycles during the gum-chewing test, did not differ between patients and controls (P = 0.10). In conclusion, patients had more oral complaints and lower bite force than controls, but did not show significantly different functional chewing patterns. Future studies should aim at integrating measurement of peak force into functional tests. Attention should be given to oral complaints of patients with MG. PeerJ Inc. 2021-06-29 /pmc/articles/PMC8253106/ /pubmed/34249511 http://dx.doi.org/10.7717/peerj.11680 Text en ©2021 Donskov et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Dentistry
Donskov, Agnete Overgaard
Shimada, Akiko
Vinge, Lotte
Svensson, Peter
Andersen, Henning
Oral function in patients with myasthenia gravis
title Oral function in patients with myasthenia gravis
title_full Oral function in patients with myasthenia gravis
title_fullStr Oral function in patients with myasthenia gravis
title_full_unstemmed Oral function in patients with myasthenia gravis
title_short Oral function in patients with myasthenia gravis
title_sort oral function in patients with myasthenia gravis
topic Dentistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253106/
https://www.ncbi.nlm.nih.gov/pubmed/34249511
http://dx.doi.org/10.7717/peerj.11680
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