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Oral function in patients with myasthenia gravis
Myasthenia Gravis (MG) is characterised by muscle weakness and increased fatigability. The aim of this pilot study was to investigate if patients with MG demonstrate different functional chewing patterns and report more complaints related to mastication as compared with healthy controls. Twelve pati...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253106/ https://www.ncbi.nlm.nih.gov/pubmed/34249511 http://dx.doi.org/10.7717/peerj.11680 |
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author | Donskov, Agnete Overgaard Shimada, Akiko Vinge, Lotte Svensson, Peter Andersen, Henning |
author_facet | Donskov, Agnete Overgaard Shimada, Akiko Vinge, Lotte Svensson, Peter Andersen, Henning |
author_sort | Donskov, Agnete Overgaard |
collection | PubMed |
description | Myasthenia Gravis (MG) is characterised by muscle weakness and increased fatigability. The aim of this pilot study was to investigate if patients with MG demonstrate different functional chewing patterns and report more complaints related to mastication as compared with healthy controls. Twelve patients (median 60 years Q1–Q3: 46–70) with generalised MG and nine healthy controls (median 57 years Q1–Q3: 55–63) participated. All participants underwent dental and oral examination and were asked to fill in a questionnaire concerning oral health. Static maximum bite force was measured with a bite force transducer, electromyography in the masseter, temporalis, and suprahyoid muscles were recorded, and jaw movement was tracked, during a 5-minute gum chewing test. The patients had more oral complaints (oral health impact profile total score 22.6 vs 7.5 P < 0.01) and had lower peak bite force than controls (18.8kgf (11.1;26.4) (95% CI) vs 29.5 kgf (21.6; 37.4) (P = 0.04)). In contrast, fatigability of the masticatory muscles, as defined by number of chewing cycles during the gum-chewing test, did not differ between patients and controls (P = 0.10). In conclusion, patients had more oral complaints and lower bite force than controls, but did not show significantly different functional chewing patterns. Future studies should aim at integrating measurement of peak force into functional tests. Attention should be given to oral complaints of patients with MG. |
format | Online Article Text |
id | pubmed-8253106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82531062021-07-08 Oral function in patients with myasthenia gravis Donskov, Agnete Overgaard Shimada, Akiko Vinge, Lotte Svensson, Peter Andersen, Henning PeerJ Dentistry Myasthenia Gravis (MG) is characterised by muscle weakness and increased fatigability. The aim of this pilot study was to investigate if patients with MG demonstrate different functional chewing patterns and report more complaints related to mastication as compared with healthy controls. Twelve patients (median 60 years Q1–Q3: 46–70) with generalised MG and nine healthy controls (median 57 years Q1–Q3: 55–63) participated. All participants underwent dental and oral examination and were asked to fill in a questionnaire concerning oral health. Static maximum bite force was measured with a bite force transducer, electromyography in the masseter, temporalis, and suprahyoid muscles were recorded, and jaw movement was tracked, during a 5-minute gum chewing test. The patients had more oral complaints (oral health impact profile total score 22.6 vs 7.5 P < 0.01) and had lower peak bite force than controls (18.8kgf (11.1;26.4) (95% CI) vs 29.5 kgf (21.6; 37.4) (P = 0.04)). In contrast, fatigability of the masticatory muscles, as defined by number of chewing cycles during the gum-chewing test, did not differ between patients and controls (P = 0.10). In conclusion, patients had more oral complaints and lower bite force than controls, but did not show significantly different functional chewing patterns. Future studies should aim at integrating measurement of peak force into functional tests. Attention should be given to oral complaints of patients with MG. PeerJ Inc. 2021-06-29 /pmc/articles/PMC8253106/ /pubmed/34249511 http://dx.doi.org/10.7717/peerj.11680 Text en ©2021 Donskov et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Dentistry Donskov, Agnete Overgaard Shimada, Akiko Vinge, Lotte Svensson, Peter Andersen, Henning Oral function in patients with myasthenia gravis |
title | Oral function in patients with myasthenia gravis |
title_full | Oral function in patients with myasthenia gravis |
title_fullStr | Oral function in patients with myasthenia gravis |
title_full_unstemmed | Oral function in patients with myasthenia gravis |
title_short | Oral function in patients with myasthenia gravis |
title_sort | oral function in patients with myasthenia gravis |
topic | Dentistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253106/ https://www.ncbi.nlm.nih.gov/pubmed/34249511 http://dx.doi.org/10.7717/peerj.11680 |
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