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Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy
It is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN is usually accompanied by disordered intestinal flora, and damaged gut barr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253186/ https://www.ncbi.nlm.nih.gov/pubmed/34187292 http://dx.doi.org/10.1080/0886022X.2021.1944875 |
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author | Xu, Xueling Wang, Huifang Guo, Dandan Man, Xiaofei Liu, Jun Li, Junying Luo, Congjuan Zhang, Ming Zhen, Li Liu, Xuemei |
author_facet | Xu, Xueling Wang, Huifang Guo, Dandan Man, Xiaofei Liu, Jun Li, Junying Luo, Congjuan Zhang, Ming Zhen, Li Liu, Xuemei |
author_sort | Xu, Xueling |
collection | PubMed |
description | It is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN is usually accompanied by disordered intestinal flora, and damaged gut barrier, which are closely related to tubulointerstitial fibrosis, and systemic inflammation. In previous studies, it has been confirmed that curcumin could alleviate tubulointerstitial fibrosis, and improve renal function through its antioxidant, anti-apoptotic, and anti-inflammatory efficacies. However, the effects curcumin exerts on intestinal flora in uric acid nephropathy are still unknown. Therefore, we used next-generation sequencing technology to investigate the effects of curcumin on gut microbiota in a rat model of UAN induced by adenine and potassium oxonate, and rats were randomly divided into control, model or curcumin treatment groups. The results demonstrated that, compared to the model group, the treatment group showed decreased serum uric acid (156.80 ± 11.90 μmol/L vs. 325.60 ± 18.65 μmol/L, p < 0.001), serum creatinine (66.20 ± 11.88 μmol/L vs. 182.20 ± 8.87 μmol/L, p < 0.001) and BUN level (13.33 ± 3.16 mmol/L vs. 36.04 ± 6.60 mmol/L, p < 0.001). The treatment group also displayed attenuated renal pathological lesions and metabolic endotoxemia (25.60 ± 5.90 ng/mL vs. 38.40 ± 4.98 ng/mL, p < 0.01), and improved tightly linked proteins expression. Besides, curcumin altered the gut microbiota structure in UAN rats. More specifically, curcumin treatment protected against the overgrowth of opportunistic pathogens in UAN, including Escherichia-Shigella and Bacteroides, and increased the relative abundance of bacteria producing short‐chain fatty acids (SCFAs), such as Lactobacillus and Ruminococcaceae. These results suggest that curcumin could modulate gut microbiota, fortify the intestinal barrier, attenuate metabolic endotoxemia, and consequently protect the renal function in UAN rats. |
format | Online Article Text |
id | pubmed-8253186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-82531862021-07-13 Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy Xu, Xueling Wang, Huifang Guo, Dandan Man, Xiaofei Liu, Jun Li, Junying Luo, Congjuan Zhang, Ming Zhen, Li Liu, Xuemei Ren Fail Laboratory Study It is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN is usually accompanied by disordered intestinal flora, and damaged gut barrier, which are closely related to tubulointerstitial fibrosis, and systemic inflammation. In previous studies, it has been confirmed that curcumin could alleviate tubulointerstitial fibrosis, and improve renal function through its antioxidant, anti-apoptotic, and anti-inflammatory efficacies. However, the effects curcumin exerts on intestinal flora in uric acid nephropathy are still unknown. Therefore, we used next-generation sequencing technology to investigate the effects of curcumin on gut microbiota in a rat model of UAN induced by adenine and potassium oxonate, and rats were randomly divided into control, model or curcumin treatment groups. The results demonstrated that, compared to the model group, the treatment group showed decreased serum uric acid (156.80 ± 11.90 μmol/L vs. 325.60 ± 18.65 μmol/L, p < 0.001), serum creatinine (66.20 ± 11.88 μmol/L vs. 182.20 ± 8.87 μmol/L, p < 0.001) and BUN level (13.33 ± 3.16 mmol/L vs. 36.04 ± 6.60 mmol/L, p < 0.001). The treatment group also displayed attenuated renal pathological lesions and metabolic endotoxemia (25.60 ± 5.90 ng/mL vs. 38.40 ± 4.98 ng/mL, p < 0.01), and improved tightly linked proteins expression. Besides, curcumin altered the gut microbiota structure in UAN rats. More specifically, curcumin treatment protected against the overgrowth of opportunistic pathogens in UAN, including Escherichia-Shigella and Bacteroides, and increased the relative abundance of bacteria producing short‐chain fatty acids (SCFAs), such as Lactobacillus and Ruminococcaceae. These results suggest that curcumin could modulate gut microbiota, fortify the intestinal barrier, attenuate metabolic endotoxemia, and consequently protect the renal function in UAN rats. Taylor & Francis 2021-06-30 /pmc/articles/PMC8253186/ /pubmed/34187292 http://dx.doi.org/10.1080/0886022X.2021.1944875 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Laboratory Study Xu, Xueling Wang, Huifang Guo, Dandan Man, Xiaofei Liu, Jun Li, Junying Luo, Congjuan Zhang, Ming Zhen, Li Liu, Xuemei Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy |
title | Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy |
title_full | Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy |
title_fullStr | Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy |
title_full_unstemmed | Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy |
title_short | Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy |
title_sort | curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy |
topic | Laboratory Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253186/ https://www.ncbi.nlm.nih.gov/pubmed/34187292 http://dx.doi.org/10.1080/0886022X.2021.1944875 |
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