Methylation of NRN1 is a novel synthetic lethal marker of PI3K‐Akt‐mTOR and ATR inhibitors in esophageal cancer

Wnt, PI3K‐Akt‐mTOR, and NF‐κB pathways were reported to be involved in DNA damage repair (DDR). DDR‐deficient cancers become critically dependent on backup DNA repair pathways. Neuritin 1 (NRN1) is reported to be involved in PI3K‐Akt‐mTOR, and its role in DDR remains unclear. Methylation‐specific PC...

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Detalles Bibliográficos
Autores principales: Du, Wushuang, Gao, Aiai, Herman, James G., Wang, Lidong, Zhang, Lirong, Jiao, Shunchang, Guo, Mingzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253287/
https://www.ncbi.nlm.nih.gov/pubmed/33931924
http://dx.doi.org/10.1111/cas.14917

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