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Etio-Hematological Profile and Clinical Correlates of Outcome of Pancytopenia in Children: Experience From a Tertiary Care Center in North India
Introduction Pancytopenia is a clinical entity encountered in pediatric practice as a feature of various benign and malignant disorders. It describes the simultaneous presence of anemia, leucopenia and thrombocytopenia. Attempts to identify the correct etiology and gauging the severity of pancytopen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253459/ https://www.ncbi.nlm.nih.gov/pubmed/34249535 http://dx.doi.org/10.7759/cureus.15382 |
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author | Alim, Muniba Verma, Nishant Kumar, Archana Pooniya, Vishal Abdul Rahman, Rafey |
author_facet | Alim, Muniba Verma, Nishant Kumar, Archana Pooniya, Vishal Abdul Rahman, Rafey |
author_sort | Alim, Muniba |
collection | PubMed |
description | Introduction Pancytopenia is a clinical entity encountered in pediatric practice as a feature of various benign and malignant disorders. It describes the simultaneous presence of anemia, leucopenia and thrombocytopenia. Attempts to identify the correct etiology and gauging the severity of pancytopenia will help to determine the management and prognosis of the patients. Objectives To study etio-hematological profile, clinical correlates and outcome of pancytopenia in Indian children Methods This prospective observational study of children with pancytopenia was conducted at a tertiary care center from August 2015 to July 2016. Clinical, hematological and bone marrow studies were performed and patients were followed for one year. The collected data were statistically analyzed. Results Out of 84 cases, the mean age at diagnosis was 70 (70.77±4.8) months. Bone marrows showed aplastic changes in 37% and hyperplasia in 14% of patients. In our study, most common causes were aplastic anemia, acute leukemia and nutritional anemia. During the first year of follow-up, 67% pancytopenics survived and 12% succumbed (rest discontinued treatment) with ~26% of aplastic anemia (7/27 cases) and 9% of acute leukemia (2/22 cases) not surviving. Anthropometric status of patients and severity in aplastic anemia were significantly associated (p < 0.05) with outcome. Conclusion The data gathered support a complex picture for pancytopenia in our study population since both benign nutritional deficiencies and malignant hematological neoplasms were common. Bone marrow studies seem to be of salient use in delineating etiology. As the outcome is multifactorial, factors like anthropometry, hematological parameters have a bearing on prognosis. |
format | Online Article Text |
id | pubmed-8253459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-82534592021-07-09 Etio-Hematological Profile and Clinical Correlates of Outcome of Pancytopenia in Children: Experience From a Tertiary Care Center in North India Alim, Muniba Verma, Nishant Kumar, Archana Pooniya, Vishal Abdul Rahman, Rafey Cureus Pediatrics Introduction Pancytopenia is a clinical entity encountered in pediatric practice as a feature of various benign and malignant disorders. It describes the simultaneous presence of anemia, leucopenia and thrombocytopenia. Attempts to identify the correct etiology and gauging the severity of pancytopenia will help to determine the management and prognosis of the patients. Objectives To study etio-hematological profile, clinical correlates and outcome of pancytopenia in Indian children Methods This prospective observational study of children with pancytopenia was conducted at a tertiary care center from August 2015 to July 2016. Clinical, hematological and bone marrow studies were performed and patients were followed for one year. The collected data were statistically analyzed. Results Out of 84 cases, the mean age at diagnosis was 70 (70.77±4.8) months. Bone marrows showed aplastic changes in 37% and hyperplasia in 14% of patients. In our study, most common causes were aplastic anemia, acute leukemia and nutritional anemia. During the first year of follow-up, 67% pancytopenics survived and 12% succumbed (rest discontinued treatment) with ~26% of aplastic anemia (7/27 cases) and 9% of acute leukemia (2/22 cases) not surviving. Anthropometric status of patients and severity in aplastic anemia were significantly associated (p < 0.05) with outcome. Conclusion The data gathered support a complex picture for pancytopenia in our study population since both benign nutritional deficiencies and malignant hematological neoplasms were common. Bone marrow studies seem to be of salient use in delineating etiology. As the outcome is multifactorial, factors like anthropometry, hematological parameters have a bearing on prognosis. Cureus 2021-06-02 /pmc/articles/PMC8253459/ /pubmed/34249535 http://dx.doi.org/10.7759/cureus.15382 Text en Copyright © 2021, Alim et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pediatrics Alim, Muniba Verma, Nishant Kumar, Archana Pooniya, Vishal Abdul Rahman, Rafey Etio-Hematological Profile and Clinical Correlates of Outcome of Pancytopenia in Children: Experience From a Tertiary Care Center in North India |
title | Etio-Hematological Profile and Clinical Correlates of Outcome of Pancytopenia in Children: Experience From a Tertiary Care Center in North India |
title_full | Etio-Hematological Profile and Clinical Correlates of Outcome of Pancytopenia in Children: Experience From a Tertiary Care Center in North India |
title_fullStr | Etio-Hematological Profile and Clinical Correlates of Outcome of Pancytopenia in Children: Experience From a Tertiary Care Center in North India |
title_full_unstemmed | Etio-Hematological Profile and Clinical Correlates of Outcome of Pancytopenia in Children: Experience From a Tertiary Care Center in North India |
title_short | Etio-Hematological Profile and Clinical Correlates of Outcome of Pancytopenia in Children: Experience From a Tertiary Care Center in North India |
title_sort | etio-hematological profile and clinical correlates of outcome of pancytopenia in children: experience from a tertiary care center in north india |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253459/ https://www.ncbi.nlm.nih.gov/pubmed/34249535 http://dx.doi.org/10.7759/cureus.15382 |
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