Impact of Structural Observables From Simulations to Predict the Effect of Single-Point Mutations in MHC Class II Peptide Binders

The prediction of peptide binders to Major Histocompatibility Complex (MHC) class II receptors is of great interest to study autoimmune diseases and for vaccine development. Most approaches predict the affinities using sequence-based models trained on experimental data and multiple alignments from k...

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Detalles Bibliográficos
Autores principales: Ochoa, Rodrigo, Laskowski, Roman A., Thornton, Janet M., Cossio, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253603/
https://www.ncbi.nlm.nih.gov/pubmed/34222328
http://dx.doi.org/10.3389/fmolb.2021.636562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253603/
https://www.ncbi.nlm.nih.gov/pubmed/34222328
http://dx.doi.org/10.3389/fmolb.2021.636562

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