Cargando…

Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform

The multiplexed cancer cell line screening platform PRISM demonstrated its utility in testing hundreds of cell lines in a single run, possessing the potential to speed up anti-cancer drug discovery, validation and optimization. Here we described the development and implementation of a next-generatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Yifeng, Ji, Xiaodong, Jang, In Sock, Surka, Christine, Hsu, Christy, Wang, Kai, Rolfe, Mark, Bence, Neil, Lu, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253734/ https://www.ncbi.nlm.nih.gov/pubmed/34215850 http://dx.doi.org/10.1038/s42003-021-02352-2

Ejemplares similares

Integrated genetic and pharmacologic interrogation of rare cancers
por: Hong, Andrew L., et al.
Publicado: (2016)

Systematic Interrogation of Angiogenesis in the Ischemic Mouse Hind Limb: Vulnerabilities and Quality Assurance
por: Lee, Jason J., et al.
Publicado: (2020)

Caribbeanist casualties: Interrogating the application of structural vulnerability to forensic anthropology
por: Dwyer, Isis, et al.
Publicado: (2023)

UBE2G1 governs the destruction of cereblon neomorphic substrates
por: Lu, Gang, et al.
Publicado: (2018)

Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities
por: Chen, Sisi, et al.
Publicado: (2016)

A multiplex CRISPR interference tool for virulence gene interrogation in Legionella pneumophila
por: Ellis, Nicole A., et al.
Publicado: (2021)

A Platform for Interrogating Cancer-Associated p53 Alleles
por: D’Brot, Alejandro, et al.
Publicado: (2016)

“TRUPATH, an Open-Source Biosensor Platform for Interrogating the GPCR Transducerome”
por: Olsen, Reid H.J., et al.
Publicado: (2020)

pHTomato: A genetically-encoded indicator that enables multiplex interrogation of synaptic activity
por: Li, Yulong, et al.
Publicado: (2012)

A scalable and tunable platform for functional interrogation of peptide hormones in fish
por: Moses, Eitan, et al.
Publicado: (2023)

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation
por: Josephy-Hernandez, Sylvia, et al.
Publicado: (2019)

Nanochannel Electroporation as a Platform for Living Cell Interrogation in Acute Myeloid Leukemia
por: Zhao, Xi, et al.
Publicado: (2015)

An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation
por: Rullan, Marc, et al.
Publicado: (2018)

Seave: a comprehensive web platform for storing and interrogating human genomic variation
por: Gayevskiy, Velimir, et al.
Publicado: (2019)

An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish
por: Sy, Samuel K. H., et al.
Publicado: (2023)

Interrogating the real /
por: Žižek, Slavoj
Publicado: (2006)

The Interrogation Mark
por: Brooke, Margaret C.
Publicado: (1925)

A platform for rapid generation of single and multiplexed reporters in human iPSC lines
por: Pei, Ying, et al.
Publicado: (2015)

A Microfluidic Platform for the Time-Resolved Interrogation of Polarized Retinal Pigment Epithelial Cells
por: Spivey, Eric C., et al.
Publicado: (2023)

Multiple wh-interrogatives in child heritage Romanian: On-line comprehension and production
por: Bentea, Anamaria, et al.
Publicado: (2022)

Microscale Interrogation of 3D Tissue Mechanics
por: Zhang, Jian, et al.
Publicado: (2019)

Interrogation of Breast Tumor-vessel Interactions in a Tissue-engineered Patient-derived Biomimetic Platform
por: Dong, Xue, et al.
Publicado: (2021)

Alpaca single B cell interrogation and heavy-chain-only antibody discovery on an optofluidic platform
por: Shapiro, Mariya B, et al.
Publicado: (2023)

Author Correction: An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish
por: Sy, Samuel K. H., et al.
Publicado: (2023)

Interrogatives about neutrinos
por: Pontecorvo, B M
Publicado: (1972)

Interrogating personhood and dementia
por: Higgs, Paul, et al.
Publicado: (2016)

Interrogative suggestibility in the elderly
por: Biondi, Silvia, et al.
Publicado: (2020)

The clinical potential of optogenetic interrogation of pathogenesis
por: Gao, Tianyu Terry, et al.
Publicado: (2023)

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion
por: Tollis, Sylvain, et al.
Publicado: (2022)

Harnessing preclinical models for the interrogation of ovarian cancer
por: Qin, Tianyu, et al.
Publicado: (2022)

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
por: Adhikari, Hema, et al.
Publicado: (2018)

A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines
por: Song, Shengli, et al.
Publicado: (2021)

A single snapshot multiplex immunoassay platform utilizing dense test lines based on engineered beads
por: Lee, Wonhyung, et al.
Publicado: (2021)

Retraction Note: A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
por: To, Jeremy, et al.
Publicado: (2021)

RETRACTED ARTICLE: A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
por: To, Jeremy, et al.
Publicado: (2021)

Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models
por: Jarzabek, M A, et al.
Publicado: (2014)

Multiplex Detection of Infectious Diseases on Microfluidic Platforms
por: Chen, Fumin, et al.
Publicado: (2023)

Carlo Rubbia interrogé: 4
Publicado: (1989)

Le CERN s'interroge
Publicado: (1962)

Proteomic Interrogation of Human Chromatin
por: Torrente, Mariana P., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_8grg06elbkq2kjroe6cgqfe7i4