Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration

A deeper understanding of early disease mechanisms occurring in Parkinson’s disease (PD) is needed to reveal restorative targets. Here we report that human induced pluripotent stem cell (iPSC)-derived dopaminergic neurons (DAn) obtained from healthy individuals or patients harboring LRRK2 PD-causing...

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Detalles Bibliográficos
Autores principales: Carola, G., Malagarriga, D., Calatayud, C., Pons-Espinal, M., Blasco-Agell, L., Richaud-Patin, Y., Fernandez-Carasa, I., Baruffi, V., Beltramone, S., Molina, E., Dell’Era, P., Toledo-Aral, J. J., Tolosa, E., Muotri, A. R., Garcia Ojalvo, J., Soriano, J., Raya, A., Consiglio, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253775/
https://www.ncbi.nlm.nih.gov/pubmed/34215735
http://dx.doi.org/10.1038/s41531-021-00198-3

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