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A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt

Delayed intracerebral hemorrhage (DICH) secondary to ventriculoperitoneal (VP) shunt is considered to be a potentially severe event. This study aimed to investigate the association between a ratio of postoperative neutrophil-to-lymphocyte ratio to preoperative neutrophil-to-lymphocyte ratio (NLRR) a...

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Autores principales: Li, Shiwei, Wang, Hongcai, Li, Feng, Chen, Maosong, Chen, Pandi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253783/
https://www.ncbi.nlm.nih.gov/pubmed/34215829
http://dx.doi.org/10.1038/s41598-021-93315-4
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author Li, Shiwei
Wang, Hongcai
Li, Feng
Chen, Maosong
Chen, Pandi
author_facet Li, Shiwei
Wang, Hongcai
Li, Feng
Chen, Maosong
Chen, Pandi
author_sort Li, Shiwei
collection PubMed
description Delayed intracerebral hemorrhage (DICH) secondary to ventriculoperitoneal (VP) shunt is considered to be a potentially severe event. This study aimed to investigate the association between a ratio of postoperative neutrophil-to-lymphocyte ratio to preoperative neutrophil-to-lymphocyte ratio (NLRR) and DICH secondary to VP shunt. We performed a retrospective review of patients who underwent VP shunt between January 2016 and June 2020. Multivariable logistic regression analysis was used to assess the association of DICH and NLRR. Then patients were divided into two groups according to the optimal cut-off point of NLRR, propensity score matching (PSM) method was performed to reconfirm the result. A total of 130 patients were enrolled and DICH occurred in 29 patients. Elevated NLRR and history of craniotomy were independent risk factors for DICH secondary to VP shunt. The optimal cut off point of NLRR was 2.05, and the sensitivity was 89.7%, the specificity was 63.4%. Patients with NLRR > 2.05 had much higher incidence of DICH (40.6% vs 4.5%). Our finding suggested that DICH following VP shunt was not a rare complication and elevated NLRR could independently predict DICH. Inflammatory responses might play an important role in the development of DICH following VP shunt.
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spelling pubmed-82537832021-07-06 A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt Li, Shiwei Wang, Hongcai Li, Feng Chen, Maosong Chen, Pandi Sci Rep Article Delayed intracerebral hemorrhage (DICH) secondary to ventriculoperitoneal (VP) shunt is considered to be a potentially severe event. This study aimed to investigate the association between a ratio of postoperative neutrophil-to-lymphocyte ratio to preoperative neutrophil-to-lymphocyte ratio (NLRR) and DICH secondary to VP shunt. We performed a retrospective review of patients who underwent VP shunt between January 2016 and June 2020. Multivariable logistic regression analysis was used to assess the association of DICH and NLRR. Then patients were divided into two groups according to the optimal cut-off point of NLRR, propensity score matching (PSM) method was performed to reconfirm the result. A total of 130 patients were enrolled and DICH occurred in 29 patients. Elevated NLRR and history of craniotomy were independent risk factors for DICH secondary to VP shunt. The optimal cut off point of NLRR was 2.05, and the sensitivity was 89.7%, the specificity was 63.4%. Patients with NLRR > 2.05 had much higher incidence of DICH (40.6% vs 4.5%). Our finding suggested that DICH following VP shunt was not a rare complication and elevated NLRR could independently predict DICH. Inflammatory responses might play an important role in the development of DICH following VP shunt. Nature Publishing Group UK 2021-07-02 /pmc/articles/PMC8253783/ /pubmed/34215829 http://dx.doi.org/10.1038/s41598-021-93315-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Shiwei
Wang, Hongcai
Li, Feng
Chen, Maosong
Chen, Pandi
A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title_full A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title_fullStr A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title_full_unstemmed A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title_short A new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
title_sort new inflammatory parameter can predict delayed intracranial hemorrhage following ventriculoperitoneal shunt
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253783/
https://www.ncbi.nlm.nih.gov/pubmed/34215829
http://dx.doi.org/10.1038/s41598-021-93315-4
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