SS18 regulates pluripotent-somatic transition through phase separation

The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the identification of SS18 as a regulator for pluripotent to somatic transition or PST by CRISPR-based whole genome screens. Mechanistically, SS18 forms m...

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Detalles Bibliográficos
Autores principales: Kuang, Junqi, Zhai, Ziwei, Li, Pengli, Shi, Ruona, Guo, Wenjing, Yao, Yuxiang, Guo, Jing, Zhao, Guoqing, He, Jiangpin, Xu, Shuyang, Wu, Chuman, Yu, Shengyong, Zhou, Chunhua, Wu, Linlin, Qin, Yue, Cai, Baomei, Li, Wei, Wu, Zichao, Li, Xiaoxi, Chu, Shilong, Yang, Tingting, Wang, Bo, Cao, Shangtao, Li, Dongwei, Zhang, Xiaofei, Chen, Jiekai, Liu, Jing, Pei, Duanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253816/
https://www.ncbi.nlm.nih.gov/pubmed/34215745
http://dx.doi.org/10.1038/s41467-021-24373-5

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