Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Tet3 is the main α-ketoglutarate (αKG)-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and further on to 5-formyl- and 5-carboxy-dC. Neurons possess high levels of 5-hydroxymethyl-dC that further increase during neural activity to establish transcriptional plastici...

Descripción completa

Detalles Bibliográficos
Autores principales: Traube, Franziska R., Özdemir, Dilara, Sahin, Hanife, Scheel, Constanze, Glück, Andrea F., Geserich, Anna S., Oganesian, Sabine, Kostidis, Sarantos, Iwan, Katharina, Rahimoff, René, Giorgio, Grazia, Müller, Markus, Spada, Fabio, Biel, Martin, Cox, Jürgen, Giera, Martin, Michalakis, Stylianos, Carell, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253819/
https://www.ncbi.nlm.nih.gov/pubmed/34215750
http://dx.doi.org/10.1038/s41467-021-24353-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253819/
https://www.ncbi.nlm.nih.gov/pubmed/34215750
http://dx.doi.org/10.1038/s41467-021-24353-9

Ejemplares similares