Cargando…

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Tet3 is the main α-ketoglutarate (αKG)-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and further on to 5-formyl- and 5-carboxy-dC. Neurons possess high levels of 5-hydroxymethyl-dC that further increase during neural activity to establish transcriptional plastici...

Descripción completa

Detalles Bibliográficos
Autores principales:	Traube, Franziska R., Özdemir, Dilara, Sahin, Hanife, Scheel, Constanze, Glück, Andrea F., Geserich, Anna S., Oganesian, Sabine, Kostidis, Sarantos, Iwan, Katharina, Rahimoff, René, Giorgio, Grazia, Müller, Markus, Spada, Fabio, Biel, Martin, Cox, Jürgen, Giera, Martin, Michalakis, Stylianos, Carell, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253819/ https://www.ncbi.nlm.nih.gov/pubmed/34215750 http://dx.doi.org/10.1038/s41467-021-24353-9

Ejemplares similares

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice
por: Murenu, Elisa, et al.
Publicado: (2021)

The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia
por: Koch, Mirja, et al.
Publicado: (2020)

TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer
por: Hua, Wan, et al.
Publicado: (2019)

Metabolomic and Lipidomic Analysis of the Colorectal Adenocarcinoma Cell Line HT29 in Hypoxia and Reoxygenation
por: Barrera, Juan Carlos Alarcon, et al.
Publicado: (2023)

Metabolic Reprogramming of Mammary Epithelial Cells during TGF-β-Induced Epithelial-to-Mesenchymal Transition
por: Hua, Wan, et al.
Publicado: (2021)

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
por: Globisch, Daniel, et al.
Publicado: (2010)

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy
por: Michalakis, Stylianos, et al.
Publicado: (2018)

Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency
por: Mulholland, Christopher B., et al.
Publicado: (2020)

Synthesis of Galactosyl‐Queuosine and Distribution of Hypermodified Q‐Nucleosides in Mouse Tissues
por: Thumbs, Peter, et al.
Publicado: (2020)

Sema7A is crucial for resolution of severe inflammation
por: Körner, Andreas, et al.
Publicado: (2021)

Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3(+)/CD141(+)) dendritic cells
por: Basit, Farhan, et al.
Publicado: (2021)

More than meets the eye: The role of microglia in healthy and diseased retina
por: Murenu, Elisa, et al.
Publicado: (2022)

Physiological roles of cGMP-gated channels: lessons from mouse models and human channelopathies
por: Biel, Martin, et al.
Publicado: (2009)

The cGMP-Dependent Protein Kinase II Is an Inhibitory Modulator of the Hyperpolarization-Activated HCN2 Channel
por: Hammelmann, Verena, et al.
Publicado: (2011)

A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network
por: Neuner, Johanna, et al.
Publicado: (2014)

Biology, Pathobiology and Gene Therapy of CNG Channel-Related Retinopathies
por: Gerhardt, Maximilian J., et al.
Publicado: (2023)

The chemistries and consequences of DNA and RNA methylation and demethylation
por: Traube, Franziska R., et al.
Publicado: (2017)

Metabolic reprogramming related to whole-chromosome instability in models for Hürthle cell carcinoma
por: Addie, Ruben D., et al.
Publicado: (2020)

AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation
por: Sekita, Yoichi, et al.
Publicado: (2021)

The Retinitis Pigmentosa Mutation c.3444+1G>A in CNGB1 Results in Skipping of Exon 32
por: Becirovic, Elvir, et al.
Publicado: (2010)

Optogenetic Control of Neural Circuits in the Mongolian Gerbil
por: Keplinger, Stefan, et al.
Publicado: (2018)

Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals
por: Mulholland, Christopher B., et al.
Publicado: (2020)

Biomimetic Iron Complex Achieves TET Enzyme Reactivity
por: Schmidl, David, et al.
Publicado: (2021)

Author Correction: Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals
por: Mulholland, Christopher B., et al.
Publicado: (2020)

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure
por: Sothilingam, Vithiyanjali, et al.
Publicado: (2016)

α-Ketoglutarate inhibits autophagy
por: Baracco, Elisa Elena, et al.
Publicado: (2019)

Altered Patterns of Compositional and Functional Disruption of the Gut Microbiota in Typhoid Fever and Nontyphoidal Febrile Illness
por: Haak, Bastiaan W, et al.
Publicado: (2020)

Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency**
por: Brandmayr, Caterina, et al.
Publicado: (2012)

Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors
por: Rieser, Ruth, et al.
Publicado: (2021)

Alpha-Ketoglutarate: Physiological Functions and Applications
por: Wu, Nan, et al.
Publicado: (2016)

Alpha-ketoglutarate for adipose tissue rejuvenation
por: Tian, Qiyu, et al.
Publicado: (2020)

Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb
por: Neuner, Johanna, et al.
Publicado: (2014)

tRNA modification profiles in obligate and moderate thermophilic bacilli
por: Panosyan, Hovik, et al.
Publicado: (2022)

Cofactor Generation Cascade for α-Ketoglutarate and Fe(II)-Dependent Dioxygenases
por: Busch, Florian, et al.
Publicado: (2020)

The Antioxidative Function of Alpha-Ketoglutarate and Its Applications
por: Liu, Shaojuan, et al.
Publicado: (2018)

Heterogeneous cellular effects of α-ketoglutarate esters
por: Galluzzi, Lorenzo
Publicado: (2019)

The Regulatory Role of α-Ketoglutarate Metabolism in Macrophages
por: Liu, Shaojuan, et al.
Publicado: (2021)

5‐Hydroxymethyl‐, 5‐Formyl‐ and 5‐Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks
por: Schelter, Florian, et al.
Publicado: (2021)

The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
por: Vatrinet, Renaud, et al.
Publicado: (2017)

Glutamate and α-ketoglutarate: key players in glioma metabolism
por: Maus, Andreas, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_crvqn6ufadhpdv54eejp82r7tl