The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival

Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages i...

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Autores principales: Valpione, Sara, Mundra, Piyushkumar A., Galvani, Elena, Campana, Luca G., Lorigan, Paul, De Rosa, Francesco, Gupta, Avinash, Weightman, John, Mills, Sarah, Dhomen, Nathalie, Marais, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253860/
https://www.ncbi.nlm.nih.gov/pubmed/34215730
http://dx.doi.org/10.1038/s41467-021-24343-x
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author Valpione, Sara
Mundra, Piyushkumar A.
Galvani, Elena
Campana, Luca G.
Lorigan, Paul
De Rosa, Francesco
Gupta, Avinash
Weightman, John
Mills, Sarah
Dhomen, Nathalie
Marais, Richard
author_facet Valpione, Sara
Mundra, Piyushkumar A.
Galvani, Elena
Campana, Luca G.
Lorigan, Paul
De Rosa, Francesco
Gupta, Avinash
Weightman, John
Mills, Sarah
Dhomen, Nathalie
Marais, Richard
author_sort Valpione, Sara
collection PubMed
description Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.
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spelling pubmed-82538602021-07-20 The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival Valpione, Sara Mundra, Piyushkumar A. Galvani, Elena Campana, Luca G. Lorigan, Paul De Rosa, Francesco Gupta, Avinash Weightman, John Mills, Sarah Dhomen, Nathalie Marais, Richard Nat Commun Article Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy. Nature Publishing Group UK 2021-07-02 /pmc/articles/PMC8253860/ /pubmed/34215730 http://dx.doi.org/10.1038/s41467-021-24343-x Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Valpione, Sara
Mundra, Piyushkumar A.
Galvani, Elena
Campana, Luca G.
Lorigan, Paul
De Rosa, Francesco
Gupta, Avinash
Weightman, John
Mills, Sarah
Dhomen, Nathalie
Marais, Richard
The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title_full The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title_fullStr The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title_full_unstemmed The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title_short The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title_sort t cell receptor repertoire of tumor infiltrating t cells is predictive and prognostic for cancer survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253860/
https://www.ncbi.nlm.nih.gov/pubmed/34215730
http://dx.doi.org/10.1038/s41467-021-24343-x
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