Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex

Methylglyoxal (MG) is a reactive and cytotoxic α-dicarbonyl byproduct of glycolysis. Our bodies have several bio-defense systems to detoxify MG, including an enzymatic system by glyoxalase (GLO) 1 and GLO2. We identified a subtype of schizophrenia patients with novel mutations in the GLO1 gene that...

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Detalles Bibliográficos
Autores principales: Toriumi, Kazuya, Berto, Stefano, Koike, Shin, Usui, Noriyoshi, Dan, Takashi, Suzuki, Kazuhiro, Miyashita, Mitsuhiro, Horiuchi, Yasue, Yoshikawa, Akane, Asakura, Mai, Nagahama, Kenichiro, Lin, Hsiao-Chun, Sugaya, Yuki, Watanabe, Takaki, Kano, Masanobu, Ogasawara, Yuki, Miyata, Toshio, Itokawa, Masanari, Konopka, Genevieve, Arai, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253914/
https://www.ncbi.nlm.nih.gov/pubmed/34198071
http://dx.doi.org/10.1016/j.redox.2021.102057

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