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On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing

Luminescence of biomolecules in the visible range of the spectrum has been experimentally observed upon aggregation, contrary to their monomeric state. However, the physical basis for this phenomenon is still elusive. Here, we systematically examine all coded amino acids to provide non-biased empiri...

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Autores principales: Arnon, Zohar A., Kreiser, Topaz, Yakimov, Boris, Brown, Noam, Aizen, Ruth, Shaham-Niv, Shira, Makam, Pandeeswar, Qaisrani, Muhammad Nawaz, Poli, Emiliano, Ruggiero, Antonella, Slutsky, Inna, Hassanali, Ali, Shirshin, Evgeny, Levy, Davide, Gazit, Ehud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253955/
https://www.ncbi.nlm.nih.gov/pubmed/34258546
http://dx.doi.org/10.1016/j.isci.2021.102695
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author Arnon, Zohar A.
Kreiser, Topaz
Yakimov, Boris
Brown, Noam
Aizen, Ruth
Shaham-Niv, Shira
Makam, Pandeeswar
Qaisrani, Muhammad Nawaz
Poli, Emiliano
Ruggiero, Antonella
Slutsky, Inna
Hassanali, Ali
Shirshin, Evgeny
Levy, Davide
Gazit, Ehud
author_facet Arnon, Zohar A.
Kreiser, Topaz
Yakimov, Boris
Brown, Noam
Aizen, Ruth
Shaham-Niv, Shira
Makam, Pandeeswar
Qaisrani, Muhammad Nawaz
Poli, Emiliano
Ruggiero, Antonella
Slutsky, Inna
Hassanali, Ali
Shirshin, Evgeny
Levy, Davide
Gazit, Ehud
author_sort Arnon, Zohar A.
collection PubMed
description Luminescence of biomolecules in the visible range of the spectrum has been experimentally observed upon aggregation, contrary to their monomeric state. However, the physical basis for this phenomenon is still elusive. Here, we systematically examine all coded amino acids to provide non-biased empirical insights. Several amino acids, including non-aromatic, show intense visible luminescence. Lysine crystals display the highest signal, whereas the very chemically similar non-coded ornithine does not, implying a role for molecular packing rather than the chemical characteristics. Furthermore, cysteine shows luminescence that is indeed crystal packing dependent as repeated rearrangements between two crystal structures result in a reversible on-off optical transition. In addition, ultrafast lifetime decay is experimentally validated, corroborating a recently raised hypothesis regarding the governing role of nπ∗ states in the emission formation. Collectively, our study supports that electronic interactions between non-fluorescent, non-absorbing molecules at the monomeric state may result in reversible optically active states by the formation of supramolecular fluorophores.
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spelling pubmed-82539552021-07-12 On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing Arnon, Zohar A. Kreiser, Topaz Yakimov, Boris Brown, Noam Aizen, Ruth Shaham-Niv, Shira Makam, Pandeeswar Qaisrani, Muhammad Nawaz Poli, Emiliano Ruggiero, Antonella Slutsky, Inna Hassanali, Ali Shirshin, Evgeny Levy, Davide Gazit, Ehud iScience Article Luminescence of biomolecules in the visible range of the spectrum has been experimentally observed upon aggregation, contrary to their monomeric state. However, the physical basis for this phenomenon is still elusive. Here, we systematically examine all coded amino acids to provide non-biased empirical insights. Several amino acids, including non-aromatic, show intense visible luminescence. Lysine crystals display the highest signal, whereas the very chemically similar non-coded ornithine does not, implying a role for molecular packing rather than the chemical characteristics. Furthermore, cysteine shows luminescence that is indeed crystal packing dependent as repeated rearrangements between two crystal structures result in a reversible on-off optical transition. In addition, ultrafast lifetime decay is experimentally validated, corroborating a recently raised hypothesis regarding the governing role of nπ∗ states in the emission formation. Collectively, our study supports that electronic interactions between non-fluorescent, non-absorbing molecules at the monomeric state may result in reversible optically active states by the formation of supramolecular fluorophores. Elsevier 2021-06-12 /pmc/articles/PMC8253955/ /pubmed/34258546 http://dx.doi.org/10.1016/j.isci.2021.102695 Text en © 2021. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Arnon, Zohar A.
Kreiser, Topaz
Yakimov, Boris
Brown, Noam
Aizen, Ruth
Shaham-Niv, Shira
Makam, Pandeeswar
Qaisrani, Muhammad Nawaz
Poli, Emiliano
Ruggiero, Antonella
Slutsky, Inna
Hassanali, Ali
Shirshin, Evgeny
Levy, Davide
Gazit, Ehud
On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing
title On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing
title_full On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing
title_fullStr On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing
title_full_unstemmed On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing
title_short On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing
title_sort on-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253955/
https://www.ncbi.nlm.nih.gov/pubmed/34258546
http://dx.doi.org/10.1016/j.isci.2021.102695
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