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On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing
Luminescence of biomolecules in the visible range of the spectrum has been experimentally observed upon aggregation, contrary to their monomeric state. However, the physical basis for this phenomenon is still elusive. Here, we systematically examine all coded amino acids to provide non-biased empiri...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253955/ https://www.ncbi.nlm.nih.gov/pubmed/34258546 http://dx.doi.org/10.1016/j.isci.2021.102695 |
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author | Arnon, Zohar A. Kreiser, Topaz Yakimov, Boris Brown, Noam Aizen, Ruth Shaham-Niv, Shira Makam, Pandeeswar Qaisrani, Muhammad Nawaz Poli, Emiliano Ruggiero, Antonella Slutsky, Inna Hassanali, Ali Shirshin, Evgeny Levy, Davide Gazit, Ehud |
author_facet | Arnon, Zohar A. Kreiser, Topaz Yakimov, Boris Brown, Noam Aizen, Ruth Shaham-Niv, Shira Makam, Pandeeswar Qaisrani, Muhammad Nawaz Poli, Emiliano Ruggiero, Antonella Slutsky, Inna Hassanali, Ali Shirshin, Evgeny Levy, Davide Gazit, Ehud |
author_sort | Arnon, Zohar A. |
collection | PubMed |
description | Luminescence of biomolecules in the visible range of the spectrum has been experimentally observed upon aggregation, contrary to their monomeric state. However, the physical basis for this phenomenon is still elusive. Here, we systematically examine all coded amino acids to provide non-biased empirical insights. Several amino acids, including non-aromatic, show intense visible luminescence. Lysine crystals display the highest signal, whereas the very chemically similar non-coded ornithine does not, implying a role for molecular packing rather than the chemical characteristics. Furthermore, cysteine shows luminescence that is indeed crystal packing dependent as repeated rearrangements between two crystal structures result in a reversible on-off optical transition. In addition, ultrafast lifetime decay is experimentally validated, corroborating a recently raised hypothesis regarding the governing role of nπ∗ states in the emission formation. Collectively, our study supports that electronic interactions between non-fluorescent, non-absorbing molecules at the monomeric state may result in reversible optically active states by the formation of supramolecular fluorophores. |
format | Online Article Text |
id | pubmed-8253955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-82539552021-07-12 On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing Arnon, Zohar A. Kreiser, Topaz Yakimov, Boris Brown, Noam Aizen, Ruth Shaham-Niv, Shira Makam, Pandeeswar Qaisrani, Muhammad Nawaz Poli, Emiliano Ruggiero, Antonella Slutsky, Inna Hassanali, Ali Shirshin, Evgeny Levy, Davide Gazit, Ehud iScience Article Luminescence of biomolecules in the visible range of the spectrum has been experimentally observed upon aggregation, contrary to their monomeric state. However, the physical basis for this phenomenon is still elusive. Here, we systematically examine all coded amino acids to provide non-biased empirical insights. Several amino acids, including non-aromatic, show intense visible luminescence. Lysine crystals display the highest signal, whereas the very chemically similar non-coded ornithine does not, implying a role for molecular packing rather than the chemical characteristics. Furthermore, cysteine shows luminescence that is indeed crystal packing dependent as repeated rearrangements between two crystal structures result in a reversible on-off optical transition. In addition, ultrafast lifetime decay is experimentally validated, corroborating a recently raised hypothesis regarding the governing role of nπ∗ states in the emission formation. Collectively, our study supports that electronic interactions between non-fluorescent, non-absorbing molecules at the monomeric state may result in reversible optically active states by the formation of supramolecular fluorophores. Elsevier 2021-06-12 /pmc/articles/PMC8253955/ /pubmed/34258546 http://dx.doi.org/10.1016/j.isci.2021.102695 Text en © 2021. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Arnon, Zohar A. Kreiser, Topaz Yakimov, Boris Brown, Noam Aizen, Ruth Shaham-Niv, Shira Makam, Pandeeswar Qaisrani, Muhammad Nawaz Poli, Emiliano Ruggiero, Antonella Slutsky, Inna Hassanali, Ali Shirshin, Evgeny Levy, Davide Gazit, Ehud On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing |
title | On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing |
title_full | On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing |
title_fullStr | On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing |
title_full_unstemmed | On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing |
title_short | On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing |
title_sort | on-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253955/ https://www.ncbi.nlm.nih.gov/pubmed/34258546 http://dx.doi.org/10.1016/j.isci.2021.102695 |
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