Isolated splenic high-grade serous carcinoma: A case report

We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial...

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Detalles Bibliográficos
Autores principales: Rogers, Ralph, Ehmann, Sarah, Tew, William P., Broach, Vance
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Reports and Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253960/
https://www.ncbi.nlm.nih.gov/pubmed/34258358
http://dx.doi.org/10.1016/j.gore.2021.100818
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author Rogers, Ralph
Ehmann, Sarah
Tew, William P.
Broach, Vance
author_facet Rogers, Ralph
Ehmann, Sarah
Tew, William P.
Broach, Vance
author_sort Rogers, Ralph
collection PubMed
description We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial Sloan Kettering–Integrated Mutation Profiling of Actionable Cancer Targets) multigene tumor panel test was performed, which revealed somatic mutations in PALB2 and in ARID1, as well as a TP53 hotspot mutation.
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spelling pubmed-82539602021-07-12 Isolated splenic high-grade serous carcinoma: A case report Rogers, Ralph Ehmann, Sarah Tew, William P. Broach, Vance Gynecol Oncol Rep Case Reports and Case Series We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial Sloan Kettering–Integrated Mutation Profiling of Actionable Cancer Targets) multigene tumor panel test was performed, which revealed somatic mutations in PALB2 and in ARID1, as well as a TP53 hotspot mutation. Elsevier 2021-06-23 /pmc/articles/PMC8253960/ /pubmed/34258358 http://dx.doi.org/10.1016/j.gore.2021.100818 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Reports and Case Series
Rogers, Ralph
Ehmann, Sarah
Tew, William P.
Broach, Vance
Isolated splenic high-grade serous carcinoma: A case report
title Isolated splenic high-grade serous carcinoma: A case report
title_full Isolated splenic high-grade serous carcinoma: A case report
title_fullStr Isolated splenic high-grade serous carcinoma: A case report
title_full_unstemmed Isolated splenic high-grade serous carcinoma: A case report
title_short Isolated splenic high-grade serous carcinoma: A case report
title_sort isolated splenic high-grade serous carcinoma: a case report
topic Case Reports and Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253960/
https://www.ncbi.nlm.nih.gov/pubmed/34258358
http://dx.doi.org/10.1016/j.gore.2021.100818
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