Cargando…

Intergenerational transmission of the patterns of functional and structural brain networks

There is clear evidence of intergenerational transmission of life values, cognitive traits, psychiatric disorders, and even aspects of daily decision making. To investigate biological substrates of this phenomenon, the brain has received increasing attention as a measurable biomarker and potential t...

Descripción completa

Detalles Bibliográficos
Autores principales: Takagi, Yu, Okada, Naohiro, Ando, Shuntaro, Yahata, Noriaki, Morita, Kentaro, Koshiyama, Daisuke, Kawakami, Shintaro, Sawada, Kingo, Koike, Shinsuke, Endo, Kaori, Yamasaki, Syudo, Nishida, Atsushi, Kasai, Kiyoto, Tanaka, Saori C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253972/
https://www.ncbi.nlm.nih.gov/pubmed/34258550
http://dx.doi.org/10.1016/j.isci.2021.102708
_version_ 1783717630605000704
author Takagi, Yu
Okada, Naohiro
Ando, Shuntaro
Yahata, Noriaki
Morita, Kentaro
Koshiyama, Daisuke
Kawakami, Shintaro
Sawada, Kingo
Koike, Shinsuke
Endo, Kaori
Yamasaki, Syudo
Nishida, Atsushi
Kasai, Kiyoto
Tanaka, Saori C
author_facet Takagi, Yu
Okada, Naohiro
Ando, Shuntaro
Yahata, Noriaki
Morita, Kentaro
Koshiyama, Daisuke
Kawakami, Shintaro
Sawada, Kingo
Koike, Shinsuke
Endo, Kaori
Yamasaki, Syudo
Nishida, Atsushi
Kasai, Kiyoto
Tanaka, Saori C
author_sort Takagi, Yu
collection PubMed
description There is clear evidence of intergenerational transmission of life values, cognitive traits, psychiatric disorders, and even aspects of daily decision making. To investigate biological substrates of this phenomenon, the brain has received increasing attention as a measurable biomarker and potential target for intervention. However, no previous study has quantitatively and comprehensively investigated the effects of intergenerational transmission on functional and structural brain networks. Here, by employing an unusually large cohort dataset (N = 84 parent-child dyads; 45 sons, 39 daughters, 81 mothers, and 3 fathers), we show that patterns of functional and structural brain networks are preserved over a generation. We also demonstrate that several demographic factors and behavioral/physiological phenotypes have a relationship with brain similarity. Collectively, our results provide a comprehensive picture of neurobiological substrates of intergenerational transmission and demonstrate the usability of our dataset for investigating the neurobiological substrates of intergenerational transmission.
format Online
Article
Text
id pubmed-8253972
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-82539722021-07-12 Intergenerational transmission of the patterns of functional and structural brain networks Takagi, Yu Okada, Naohiro Ando, Shuntaro Yahata, Noriaki Morita, Kentaro Koshiyama, Daisuke Kawakami, Shintaro Sawada, Kingo Koike, Shinsuke Endo, Kaori Yamasaki, Syudo Nishida, Atsushi Kasai, Kiyoto Tanaka, Saori C iScience Article There is clear evidence of intergenerational transmission of life values, cognitive traits, psychiatric disorders, and even aspects of daily decision making. To investigate biological substrates of this phenomenon, the brain has received increasing attention as a measurable biomarker and potential target for intervention. However, no previous study has quantitatively and comprehensively investigated the effects of intergenerational transmission on functional and structural brain networks. Here, by employing an unusually large cohort dataset (N = 84 parent-child dyads; 45 sons, 39 daughters, 81 mothers, and 3 fathers), we show that patterns of functional and structural brain networks are preserved over a generation. We also demonstrate that several demographic factors and behavioral/physiological phenotypes have a relationship with brain similarity. Collectively, our results provide a comprehensive picture of neurobiological substrates of intergenerational transmission and demonstrate the usability of our dataset for investigating the neurobiological substrates of intergenerational transmission. Elsevier 2021-06-11 /pmc/articles/PMC8253972/ /pubmed/34258550 http://dx.doi.org/10.1016/j.isci.2021.102708 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takagi, Yu
Okada, Naohiro
Ando, Shuntaro
Yahata, Noriaki
Morita, Kentaro
Koshiyama, Daisuke
Kawakami, Shintaro
Sawada, Kingo
Koike, Shinsuke
Endo, Kaori
Yamasaki, Syudo
Nishida, Atsushi
Kasai, Kiyoto
Tanaka, Saori C
Intergenerational transmission of the patterns of functional and structural brain networks
title Intergenerational transmission of the patterns of functional and structural brain networks
title_full Intergenerational transmission of the patterns of functional and structural brain networks
title_fullStr Intergenerational transmission of the patterns of functional and structural brain networks
title_full_unstemmed Intergenerational transmission of the patterns of functional and structural brain networks
title_short Intergenerational transmission of the patterns of functional and structural brain networks
title_sort intergenerational transmission of the patterns of functional and structural brain networks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253972/
https://www.ncbi.nlm.nih.gov/pubmed/34258550
http://dx.doi.org/10.1016/j.isci.2021.102708
work_keys_str_mv AT takagiyu intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT okadanaohiro intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT andoshuntaro intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT yahatanoriaki intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT moritakentaro intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT koshiyamadaisuke intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT kawakamishintaro intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT sawadakingo intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT koikeshinsuke intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT endokaori intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT yamasakisyudo intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT nishidaatsushi intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT kasaikiyoto intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks
AT tanakasaoric intergenerationaltransmissionofthepatternsoffunctionalandstructuralbrainnetworks