An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids

Cellular growth and proliferation are primarily dictated by the mechanistic target of rapamycin complex 1 (mTORC1), which balances nutrient availability against the cell’s anabolic needs. Central to the activity of mTORC1 is the RagA–RagC GTPase heterodimer, which under favorable conditions recruits...

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Detalles Bibliográficos
Autores principales: Egri, Shawn B., Shen, Kuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254048/
https://www.ncbi.nlm.nih.gov/pubmed/34116056
http://dx.doi.org/10.1016/j.jbc.2021.100861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254048/
https://www.ncbi.nlm.nih.gov/pubmed/34116056
http://dx.doi.org/10.1016/j.jbc.2021.100861

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