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An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids
Cellular growth and proliferation are primarily dictated by the mechanistic target of rapamycin complex 1 (mTORC1), which balances nutrient availability against the cell’s anabolic needs. Central to the activity of mTORC1 is the RagA–RagC GTPase heterodimer, which under favorable conditions recruits...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254048/ https://www.ncbi.nlm.nih.gov/pubmed/34116056 http://dx.doi.org/10.1016/j.jbc.2021.100861 |