New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma

Mesenchymal stem cells (MSCs) are multipotent stem cells with significant potential for regenerative medicine. The tumorigenesis of osteosarcoma is an intricate system and MSCs act as an indispensable part of this, interacting with the tumor microenvironment (TME) during the process. MSCs link to ce...

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Detalles Bibliográficos
Autores principales: Chang, Xingyu, Ma, Zhanjun, Zhu, Guomao, Lu, Yubao, Yang, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254115/
https://www.ncbi.nlm.nih.gov/pubmed/34258182
http://dx.doi.org/10.1016/j.jbo.2021.100372
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author Chang, Xingyu
Ma, Zhanjun
Zhu, Guomao
Lu, Yubao
Yang, Jingjing
author_facet Chang, Xingyu
Ma, Zhanjun
Zhu, Guomao
Lu, Yubao
Yang, Jingjing
author_sort Chang, Xingyu
collection PubMed
description Mesenchymal stem cells (MSCs) are multipotent stem cells with significant potential for regenerative medicine. The tumorigenesis of osteosarcoma is an intricate system and MSCs act as an indispensable part of this, interacting with the tumor microenvironment (TME) during the process. MSCs link to cells by acting on each component in the TME via autocrine or paracrine extracellular vesicles for cellular communication. Because of their unique characteristics, MSCs can be modified and processed into good biological carriers, loaded with drugs, and transfected with anticancer genes for the targeted treatment of osteosarcoma. Previous high-quality reviews have described the biological characteristics of MSCs; this review will discuss the effects of MSCs on the components of the TME and cellular communication and the prospects for clinical applications of MSCs.
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spelling pubmed-82541152021-07-12 New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma Chang, Xingyu Ma, Zhanjun Zhu, Guomao Lu, Yubao Yang, Jingjing J Bone Oncol Review Article Mesenchymal stem cells (MSCs) are multipotent stem cells with significant potential for regenerative medicine. The tumorigenesis of osteosarcoma is an intricate system and MSCs act as an indispensable part of this, interacting with the tumor microenvironment (TME) during the process. MSCs link to cells by acting on each component in the TME via autocrine or paracrine extracellular vesicles for cellular communication. Because of their unique characteristics, MSCs can be modified and processed into good biological carriers, loaded with drugs, and transfected with anticancer genes for the targeted treatment of osteosarcoma. Previous high-quality reviews have described the biological characteristics of MSCs; this review will discuss the effects of MSCs on the components of the TME and cellular communication and the prospects for clinical applications of MSCs. Elsevier 2021-06-23 /pmc/articles/PMC8254115/ /pubmed/34258182 http://dx.doi.org/10.1016/j.jbo.2021.100372 Text en © 2021 The Authors. Published by Elsevier GmbH. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Chang, Xingyu
Ma, Zhanjun
Zhu, Guomao
Lu, Yubao
Yang, Jingjing
New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma
title New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma
title_full New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma
title_fullStr New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma
title_full_unstemmed New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma
title_short New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma
title_sort new perspective into mesenchymal stem cells: molecular mechanisms regulating osteosarcoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254115/
https://www.ncbi.nlm.nih.gov/pubmed/34258182
http://dx.doi.org/10.1016/j.jbo.2021.100372
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