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Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer
Anatomical changes during chemoradiation for lung cancer may decrease dose to the target or increase dose to organs at risk. To assess our ability to identify clinically significant anatomical alterations, we followed 67 lung cancer patients by daily cone-beam CT scans to ensure correct patient posi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254190/ https://www.ncbi.nlm.nih.gov/pubmed/34258408 http://dx.doi.org/10.1016/j.phro.2021.04.003 |
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author | Bjaanæs, Maria Moksnes Sande, Erlend Peter Skaug Loe, Øyvind Ramberg, Christina Næss, Tove Mette Ottestad, Andreas Rogg, Lotte V. Svestad, Jørund Graadal Haakensen, Vilde Drageset |
author_facet | Bjaanæs, Maria Moksnes Sande, Erlend Peter Skaug Loe, Øyvind Ramberg, Christina Næss, Tove Mette Ottestad, Andreas Rogg, Lotte V. Svestad, Jørund Graadal Haakensen, Vilde Drageset |
author_sort | Bjaanæs, Maria Moksnes |
collection | PubMed |
description | Anatomical changes during chemoradiation for lung cancer may decrease dose to the target or increase dose to organs at risk. To assess our ability to identify clinically significant anatomical alterations, we followed 67 lung cancer patients by daily cone-beam CT scans to ensure correct patient positioning and observe anatomical alterations. We also re-calculated the original dose distribution on a planned control CT scan obtained halfway during the treatment course to identify anatomical changes that potentially affected doses to the target or organs at risk. Of 66 patients who completed the treatment, 12 patients needed adaptation, two patients were adapted twice. We conclude that daily cone-beam CT and routines at the treatment machine discover relevant anatomical changes during curative radiotherapy for patients with lung cancer without additional imaging. |
format | Online Article Text |
id | pubmed-8254190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-82541902021-07-12 Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer Bjaanæs, Maria Moksnes Sande, Erlend Peter Skaug Loe, Øyvind Ramberg, Christina Næss, Tove Mette Ottestad, Andreas Rogg, Lotte V. Svestad, Jørund Graadal Haakensen, Vilde Drageset Phys Imaging Radiat Oncol Short Communication Anatomical changes during chemoradiation for lung cancer may decrease dose to the target or increase dose to organs at risk. To assess our ability to identify clinically significant anatomical alterations, we followed 67 lung cancer patients by daily cone-beam CT scans to ensure correct patient positioning and observe anatomical alterations. We also re-calculated the original dose distribution on a planned control CT scan obtained halfway during the treatment course to identify anatomical changes that potentially affected doses to the target or organs at risk. Of 66 patients who completed the treatment, 12 patients needed adaptation, two patients were adapted twice. We conclude that daily cone-beam CT and routines at the treatment machine discover relevant anatomical changes during curative radiotherapy for patients with lung cancer without additional imaging. Elsevier 2021-05-08 /pmc/articles/PMC8254190/ /pubmed/34258408 http://dx.doi.org/10.1016/j.phro.2021.04.003 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Short Communication Bjaanæs, Maria Moksnes Sande, Erlend Peter Skaug Loe, Øyvind Ramberg, Christina Næss, Tove Mette Ottestad, Andreas Rogg, Lotte V. Svestad, Jørund Graadal Haakensen, Vilde Drageset Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer |
title | Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer |
title_full | Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer |
title_fullStr | Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer |
title_full_unstemmed | Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer |
title_short | Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer |
title_sort | improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254190/ https://www.ncbi.nlm.nih.gov/pubmed/34258408 http://dx.doi.org/10.1016/j.phro.2021.04.003 |
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