ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA

BACKGROUND: Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifications and whether cells distinguish aberrant from canonical methylations. METHODS: Here we use quan...

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Detalles Bibliográficos
Autores principales: Wollen, Kristian Lied, Hagen, Lars, Vågbø, Cathrine B., Rabe, Renana, Iveland, Tobias S., Aas, Per Arne, Sharma, Animesh, Sporsheim, Bjørnar, Erlandsen, Hilde O., Palibrk, Vuk, Bjørås, Magnar, Fonseca, Davi M., Mosammaparast, Nima, Slupphaug, Geir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254245/
https://www.ncbi.nlm.nih.gov/pubmed/34217309
http://dx.doi.org/10.1186/s12967-021-02948-6

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