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Are Anti-Inflammatory Cytokines Associated with Cognitive Impairment in Patients with Insomnia Comorbid with Depression? A Pilot Study

BACKGROUND: To distinguish insomnia comorbid with depression (ICD) from chronic insomnia disorder (CID) by exploring the relationship between serum levels of frequently overlooked anti-inflammatory cytokines and cognitive function. METHODS: A total of 42 ICD patients, 63 CID patients, and 42 healthy...

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Autores principales: He, Shuo, Chen, Xi-Xi, Ge, Wei, Yang, Shuai, Chen, Jun-Tao, Niu, Jing-Wen, Xia, Lan, Chen, Gui-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254552/
https://www.ncbi.nlm.nih.gov/pubmed/34234602
http://dx.doi.org/10.2147/NSS.S312272
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author He, Shuo
Chen, Xi-Xi
Ge, Wei
Yang, Shuai
Chen, Jun-Tao
Niu, Jing-Wen
Xia, Lan
Chen, Gui-Hai
author_facet He, Shuo
Chen, Xi-Xi
Ge, Wei
Yang, Shuai
Chen, Jun-Tao
Niu, Jing-Wen
Xia, Lan
Chen, Gui-Hai
author_sort He, Shuo
collection PubMed
description BACKGROUND: To distinguish insomnia comorbid with depression (ICD) from chronic insomnia disorder (CID) by exploring the relationship between serum levels of frequently overlooked anti-inflammatory cytokines and cognitive function. METHODS: A total of 42 ICD patients, 63 CID patients, and 42 healthy control subjects were enrolled in the study. The Pittsburgh Sleep Quality Index and Hamilton Depression Rating Scale were used to assess sleep quality and depression severity, respectively. The Chinese-Beijing version of Montreal Cognitive Assessment scale (MoCA-C) and Nine-Box Maze Test (NBMT) were used to assess cognitive function. Serum levels of anti-inflammatory interleukins (IL-1RA, IL-4, IL-5, IL-10, IL-13, and IL-28A), transforming growth factor (TGF)-β1, granulocyte-macrophage colony-stimulating factor, interferon-γ, and the chemokine regulated upon activation, normal T cell expressed and secreted (RANTES) were measured by enzyme-linked immunosorbent assay. RESULTS: The ICD group had significantly more errors in the spatial reference task (H=2.55, P(s)=0.03) and spatial working memory task (H=5.67, P(s)<0.01) of the NBMT, as well as lower levels of IL-1RA (H=−2.85, P(s)=0.01), IL-4 (H=−3.28, P(s)<0.01), IL-5 (H=−3.35, P(s)<0.01), IL-10 (H=−4.46, P(s)<0.01), and IL-28A (H=−2.75, P(s)=0.02) than control subjects. Compared with the CID group, the ICD group had significantly more errors in the spatial reference memory task (H=−2.84, P(s)=0.01) of the NBMT, and lower levels of IL-5 (H=3.41, P(s)<0.01), IL-10 (H=5.30, P(s)<0.01), IL-13 (H=3.89, P(s)<0.01), and GM-CSF (H=2.72, P(s)=0.02). A partial correlation analysis showed that the level of one or more of IL-4, IL-5, IL-10, IL-13, and TGF-β1 was positively correlated with cognitive function (MoCA-C score and/or performance in spatial memory task) in ICD patients. CONCLUSION: ICD is a distinct condition that can be distinguished from CID based on immune dysfunction and specific types of cognitive dysfunction.
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spelling pubmed-82545522021-07-06 Are Anti-Inflammatory Cytokines Associated with Cognitive Impairment in Patients with Insomnia Comorbid with Depression? A Pilot Study He, Shuo Chen, Xi-Xi Ge, Wei Yang, Shuai Chen, Jun-Tao Niu, Jing-Wen Xia, Lan Chen, Gui-Hai Nat Sci Sleep Original Research BACKGROUND: To distinguish insomnia comorbid with depression (ICD) from chronic insomnia disorder (CID) by exploring the relationship between serum levels of frequently overlooked anti-inflammatory cytokines and cognitive function. METHODS: A total of 42 ICD patients, 63 CID patients, and 42 healthy control subjects were enrolled in the study. The Pittsburgh Sleep Quality Index and Hamilton Depression Rating Scale were used to assess sleep quality and depression severity, respectively. The Chinese-Beijing version of Montreal Cognitive Assessment scale (MoCA-C) and Nine-Box Maze Test (NBMT) were used to assess cognitive function. Serum levels of anti-inflammatory interleukins (IL-1RA, IL-4, IL-5, IL-10, IL-13, and IL-28A), transforming growth factor (TGF)-β1, granulocyte-macrophage colony-stimulating factor, interferon-γ, and the chemokine regulated upon activation, normal T cell expressed and secreted (RANTES) were measured by enzyme-linked immunosorbent assay. RESULTS: The ICD group had significantly more errors in the spatial reference task (H=2.55, P(s)=0.03) and spatial working memory task (H=5.67, P(s)<0.01) of the NBMT, as well as lower levels of IL-1RA (H=−2.85, P(s)=0.01), IL-4 (H=−3.28, P(s)<0.01), IL-5 (H=−3.35, P(s)<0.01), IL-10 (H=−4.46, P(s)<0.01), and IL-28A (H=−2.75, P(s)=0.02) than control subjects. Compared with the CID group, the ICD group had significantly more errors in the spatial reference memory task (H=−2.84, P(s)=0.01) of the NBMT, and lower levels of IL-5 (H=3.41, P(s)<0.01), IL-10 (H=5.30, P(s)<0.01), IL-13 (H=3.89, P(s)<0.01), and GM-CSF (H=2.72, P(s)=0.02). A partial correlation analysis showed that the level of one or more of IL-4, IL-5, IL-10, IL-13, and TGF-β1 was positively correlated with cognitive function (MoCA-C score and/or performance in spatial memory task) in ICD patients. CONCLUSION: ICD is a distinct condition that can be distinguished from CID based on immune dysfunction and specific types of cognitive dysfunction. Dove 2021-06-29 /pmc/articles/PMC8254552/ /pubmed/34234602 http://dx.doi.org/10.2147/NSS.S312272 Text en © 2021 He et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
He, Shuo
Chen, Xi-Xi
Ge, Wei
Yang, Shuai
Chen, Jun-Tao
Niu, Jing-Wen
Xia, Lan
Chen, Gui-Hai
Are Anti-Inflammatory Cytokines Associated with Cognitive Impairment in Patients with Insomnia Comorbid with Depression? A Pilot Study
title Are Anti-Inflammatory Cytokines Associated with Cognitive Impairment in Patients with Insomnia Comorbid with Depression? A Pilot Study
title_full Are Anti-Inflammatory Cytokines Associated with Cognitive Impairment in Patients with Insomnia Comorbid with Depression? A Pilot Study
title_fullStr Are Anti-Inflammatory Cytokines Associated with Cognitive Impairment in Patients with Insomnia Comorbid with Depression? A Pilot Study
title_full_unstemmed Are Anti-Inflammatory Cytokines Associated with Cognitive Impairment in Patients with Insomnia Comorbid with Depression? A Pilot Study
title_short Are Anti-Inflammatory Cytokines Associated with Cognitive Impairment in Patients with Insomnia Comorbid with Depression? A Pilot Study
title_sort are anti-inflammatory cytokines associated with cognitive impairment in patients with insomnia comorbid with depression? a pilot study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254552/
https://www.ncbi.nlm.nih.gov/pubmed/34234602
http://dx.doi.org/10.2147/NSS.S312272
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