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Complicity of α-synuclein oligomer and calcium dyshomeostasis in selective neuronal vulnerability in Lewy body disease
α-Synuclein oligomers and Ca(2+) dyshomeostasis have been thoroughly investigated with respect to the pathogenesis of Lewy body disease (LBD). In LBD, α-synuclein oligomers exhibit a neuron-specific cytoplasmic distribution. Highly active neurons and neurons with a high Ca(2+) burden are prone to da...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Pharmaceutical Society of Korea
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254713/ https://www.ncbi.nlm.nih.gov/pubmed/34114191 http://dx.doi.org/10.1007/s12272-021-01334-6 |