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Differential expression of miRNAs and functional role of mir-200a in high and low productivity CHO cells expressing an Fc fusion protein

OBJECTIVES: We used miRNA and proteomic profiling to understand intracellular pathways that contribute to high and low specific productivity (Qp) phenotypes in CHO clonally derived cell lines (CDCLs) from the same cell line generation project. RESULTS: Differentially expressed (DE) miRNAs were ident...

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Detalles Bibliográficos
Autores principales:	Bryan, Laura, Henry, Michael, Barron, Niall, Gallagher, Clair, Kelly, Ronan M., Frye, Christopher C., Osborne, Matthew D., Clynes, Martin, Meleady, Paula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2021
Materias:	Original Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254715/ https://www.ncbi.nlm.nih.gov/pubmed/34131805 http://dx.doi.org/10.1007/s10529-021-03153-7

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