Effect of HSP90AB1 and CC domain interaction on Bcr-Abl protein cytoplasm localization and function in chronic myeloid leukemia cells

BACKGROUND: The fusion oncoprotein Bcr-Abl is mostly located in the cytoplasm, which causes chronic myeloid leukemia (CML). After moving into the nucleus, the fusion protein can induce apoptosis of CML cells. The coiled-coil domain (CC domain) of Bcr-Abl protein plays a central role in the subcellul...

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Detalles Bibliográficos
Autores principales: Peng, Yuhang, Huang, Zhenglan, Zhou, Fangzhu, Wang, Teng, Mou, Ke, Feng, Wenli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254927/
https://www.ncbi.nlm.nih.gov/pubmed/34217296
http://dx.doi.org/10.1186/s12964-021-00752-9

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