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Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice

Histone modifications are a key mechanism underlying the epigenetic regulation of gene expression, which is critically involved in the consolidation of multiple forms of memory. However, the roles of histone modifications in cerebellum-dependent motor learning and memory are not well understood. To...

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Detalles Bibliográficos
Autores principales: Kim, Yong Gyu, Bak, Myeong Seong, Kim, Ahbin, Kim, Yujin, Chae, Yun-Cheol, Kim, Ye Lee, Chun, Yang-Sook, An, Joon-Yong, Seo, Sang-Beom, Kim, Sang Jeong, Lee, Yong-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254933/
https://www.ncbi.nlm.nih.gov/pubmed/34217333
http://dx.doi.org/10.1186/s13041-021-00815-5
Descripción
Sumario:Histone modifications are a key mechanism underlying the epigenetic regulation of gene expression, which is critically involved in the consolidation of multiple forms of memory. However, the roles of histone modifications in cerebellum-dependent motor learning and memory are not well understood. To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b(+/−)) mice, which show reduced lysine 9 on histone 3 (H3K9) demethylase activity. H3K9 di-methylation is significantly increased selectively in the granule cell layer of the cerebellum of Kdm3b(+/−) mice. In the cerebellum-dependent optokinetic response (OKR) learning, Kdm3b(+/−) mice show deficits in memory consolidation, whereas they are normal in basal oculomotor performance and OKR acquisition. In addition, RNA-seq analyses revealed that the expression levels of several plasticity-related genes were altered in the mutant cerebellum. Our study suggests that active regulation of histone methylation is critical for the consolidation of cerebellar motor memory. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13041-021-00815-5.