JMJD3: a critical epigenetic regulator in stem cell fate

The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with transcriptional silencing. JMJD3 has been studied extensively in immune diseases, cancer, and tu...

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Detalles Bibliográficos
Autores principales: Ding, Yuanjie, Yao, Yuanchun, Gong, Xingmu, Zhuo, Qi, Chen, Jinhua, Tian, Miao, Farzaneh, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254972/
https://www.ncbi.nlm.nih.gov/pubmed/34217316
http://dx.doi.org/10.1186/s12964-021-00753-8
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author Ding, Yuanjie
Yao, Yuanchun
Gong, Xingmu
Zhuo, Qi
Chen, Jinhua
Tian, Miao
Farzaneh, Maryam
author_facet Ding, Yuanjie
Yao, Yuanchun
Gong, Xingmu
Zhuo, Qi
Chen, Jinhua
Tian, Miao
Farzaneh, Maryam
author_sort Ding, Yuanjie
collection PubMed
description The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with transcriptional silencing. JMJD3 has been studied extensively in immune diseases, cancer, and tumor development. There is a comprehensive epigenetic transformation during the transition of embryonic stem cells (ESCs) into specialized cells or the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs). Recent studies have illustrated that JMJD3 plays a major role in cell fate determination of pluripotent and multipotent stem cells (MSCs). JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and MSCs. In this review, we will focus on the recent advances of JMJD3 function in stem cell fate. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-021-00753-8.
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spelling pubmed-82549722021-07-06 JMJD3: a critical epigenetic regulator in stem cell fate Ding, Yuanjie Yao, Yuanchun Gong, Xingmu Zhuo, Qi Chen, Jinhua Tian, Miao Farzaneh, Maryam Cell Commun Signal Review The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with transcriptional silencing. JMJD3 has been studied extensively in immune diseases, cancer, and tumor development. There is a comprehensive epigenetic transformation during the transition of embryonic stem cells (ESCs) into specialized cells or the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs). Recent studies have illustrated that JMJD3 plays a major role in cell fate determination of pluripotent and multipotent stem cells (MSCs). JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and MSCs. In this review, we will focus on the recent advances of JMJD3 function in stem cell fate. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-021-00753-8. BioMed Central 2021-07-03 /pmc/articles/PMC8254972/ /pubmed/34217316 http://dx.doi.org/10.1186/s12964-021-00753-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ding, Yuanjie
Yao, Yuanchun
Gong, Xingmu
Zhuo, Qi
Chen, Jinhua
Tian, Miao
Farzaneh, Maryam
JMJD3: a critical epigenetic regulator in stem cell fate
title JMJD3: a critical epigenetic regulator in stem cell fate
title_full JMJD3: a critical epigenetic regulator in stem cell fate
title_fullStr JMJD3: a critical epigenetic regulator in stem cell fate
title_full_unstemmed JMJD3: a critical epigenetic regulator in stem cell fate
title_short JMJD3: a critical epigenetic regulator in stem cell fate
title_sort jmjd3: a critical epigenetic regulator in stem cell fate
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254972/
https://www.ncbi.nlm.nih.gov/pubmed/34217316
http://dx.doi.org/10.1186/s12964-021-00753-8
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