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IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study
BACKGROUND: Little is known about the clinical value of Insulin-like growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, in an elderly general population with multiple co-morbidities and high prevalence of asymptomatic cardiovascular ventricular dysfunction. Inflammation and fibr...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254994/ https://www.ncbi.nlm.nih.gov/pubmed/34217226 http://dx.doi.org/10.1186/s12872-021-02138-8 |
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author | Meessen, Jennifer M. T. A. Cesaroni, Giulia Mureddu, Gian F. Boccanelli, Alessandro Wienhues-Thelen, Ursula-Henrike Kastner, Peter Ojeda-Fernandez, Luisa Novelli, Deborah Bazzoni, Gianfranco Mangiavacchi, Maurizio Agabiti, Nera Masson, Serge Staszewsky, Lidia Latini, Roberto |
author_facet | Meessen, Jennifer M. T. A. Cesaroni, Giulia Mureddu, Gian F. Boccanelli, Alessandro Wienhues-Thelen, Ursula-Henrike Kastner, Peter Ojeda-Fernandez, Luisa Novelli, Deborah Bazzoni, Gianfranco Mangiavacchi, Maurizio Agabiti, Nera Masson, Serge Staszewsky, Lidia Latini, Roberto |
author_sort | Meessen, Jennifer M. T. A. |
collection | PubMed |
description | BACKGROUND: Little is known about the clinical value of Insulin-like growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, in an elderly general population with multiple co-morbidities and high prevalence of asymptomatic cardiovascular ventricular dysfunction. Inflammation and fibrosis are hallmarks of cardiac aging and remodelling. Therefore, we assessed the clinical performance of IGFBP7 and two other biomarkers reflecting these pathogenic pathways, the growth differentiation factor-15 (GFD-15) and amino-terminal propeptide of type I procollagen (P1NP), for their association with cardiac phenotypes and outcomes in the PREDICTOR study. METHODS: 2001 community-dwelling subjects aged 65–84 years who had undergone centrally-read echocardiography, were selected through administrative registries. Atrial fibrillation (AF) and 4 echocardiographic patterns were assessed: E/e’ (> 8), enlarged left atrial area, left ventricular hypertrophy (LVH) and reduced midwall circumference shortening (MFS). All-cause and cardiovascular mortality and hospitalization were recorded over a median follow-up of 10.6 years. RESULTS: IGFBP7 and GDF-15, but not P1NP, were independently associated with prevalent AF and echocardiographic variables after adjusting for age and sex. After adjustment for clinical risk factors and cardiac patterns or NT-proBNP and hsTnT, both IGFBP7 and GDF-15 independently predicted all-cause mortality, hazard ratios 2.13[1.08–4.22] and 2.03[1.62–2.56] per unit increase of Ln-transformed markers, respectively. CONCLUSIONS: In a community-based elderly cohort, IGFBP7 and GDF-15 appear associated to cardiac alterations as well as to 10-year risk of all-cause mortality. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-021-02138-8. |
format | Online Article Text |
id | pubmed-8254994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82549942021-07-06 IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study Meessen, Jennifer M. T. A. Cesaroni, Giulia Mureddu, Gian F. Boccanelli, Alessandro Wienhues-Thelen, Ursula-Henrike Kastner, Peter Ojeda-Fernandez, Luisa Novelli, Deborah Bazzoni, Gianfranco Mangiavacchi, Maurizio Agabiti, Nera Masson, Serge Staszewsky, Lidia Latini, Roberto BMC Cardiovasc Disord Research Article BACKGROUND: Little is known about the clinical value of Insulin-like growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, in an elderly general population with multiple co-morbidities and high prevalence of asymptomatic cardiovascular ventricular dysfunction. Inflammation and fibrosis are hallmarks of cardiac aging and remodelling. Therefore, we assessed the clinical performance of IGFBP7 and two other biomarkers reflecting these pathogenic pathways, the growth differentiation factor-15 (GFD-15) and amino-terminal propeptide of type I procollagen (P1NP), for their association with cardiac phenotypes and outcomes in the PREDICTOR study. METHODS: 2001 community-dwelling subjects aged 65–84 years who had undergone centrally-read echocardiography, were selected through administrative registries. Atrial fibrillation (AF) and 4 echocardiographic patterns were assessed: E/e’ (> 8), enlarged left atrial area, left ventricular hypertrophy (LVH) and reduced midwall circumference shortening (MFS). All-cause and cardiovascular mortality and hospitalization were recorded over a median follow-up of 10.6 years. RESULTS: IGFBP7 and GDF-15, but not P1NP, were independently associated with prevalent AF and echocardiographic variables after adjusting for age and sex. After adjustment for clinical risk factors and cardiac patterns or NT-proBNP and hsTnT, both IGFBP7 and GDF-15 independently predicted all-cause mortality, hazard ratios 2.13[1.08–4.22] and 2.03[1.62–2.56] per unit increase of Ln-transformed markers, respectively. CONCLUSIONS: In a community-based elderly cohort, IGFBP7 and GDF-15 appear associated to cardiac alterations as well as to 10-year risk of all-cause mortality. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-021-02138-8. BioMed Central 2021-07-03 /pmc/articles/PMC8254994/ /pubmed/34217226 http://dx.doi.org/10.1186/s12872-021-02138-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Meessen, Jennifer M. T. A. Cesaroni, Giulia Mureddu, Gian F. Boccanelli, Alessandro Wienhues-Thelen, Ursula-Henrike Kastner, Peter Ojeda-Fernandez, Luisa Novelli, Deborah Bazzoni, Gianfranco Mangiavacchi, Maurizio Agabiti, Nera Masson, Serge Staszewsky, Lidia Latini, Roberto IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
title | IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
title_full | IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
title_fullStr | IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
title_full_unstemmed | IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
title_short | IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
title_sort | igfbp7 and gdf-15, but not p1np, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254994/ https://www.ncbi.nlm.nih.gov/pubmed/34217226 http://dx.doi.org/10.1186/s12872-021-02138-8 |
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