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Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study
BACKGROUND: Although uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known. We evaluated whether UA level is associated with coronary artery calc...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255010/ https://www.ncbi.nlm.nih.gov/pubmed/34218791 http://dx.doi.org/10.1186/s12882-021-02463-2 |
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author | Han, Miyeun Kim, Hyunsuk Kim, Hyo Jin Kang, Eunjeong Kim, Yong-Soo Choi, Kyu Hun Kim, Soo Wan Ahn, Curie Oh, Kook-Hwan |
author_facet | Han, Miyeun Kim, Hyunsuk Kim, Hyo Jin Kang, Eunjeong Kim, Yong-Soo Choi, Kyu Hun Kim, Soo Wan Ahn, Curie Oh, Kook-Hwan |
author_sort | Han, Miyeun |
collection | PubMed |
description | BACKGROUND: Although uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known. We evaluated whether UA level is associated with coronary artery calcium (CAC) score in a predialysis CKD cohort. METHODS: A total of 1,350 subjects who underwent coronary computed tomography as part of the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease were analysed. We conducted a logistic regression analysis to evaluate the association between UA and the presence of CAC. RESULTS: CAC was detected in 705 (52.2 %) patients, and the level of UA was significantly higher in CAC > 0 patients. UA showed a positive relationship with CAC > 0 in age- and sex-adjusted logistic regression analysis (Odds ratio (OR) 1.11, 95 % confidence interval (CI) 1.04–1.19, P = 0.003). However, UA showed no association with CAC > 0 in multivariate analysis. Further analysis showed that UA showed a positive association with CAC > 0 only in estimated glomerual filtration rate (eGFR) > 60 ml/min/1.73 m(2) (OR 1.23, 95 % CI 1.02–1.49, P = 0.036) but not in eGFR 30–59 ml/min/1.73 m(2) (OR 0.92, 95 % CI 0.78–1.08, P = 0.309) or < 30 ml/min/1.73 m(2) (OR 0.92, 95 % CI 0.79–1.08, P = 0.426). CONCLUSIONS: UA level was significantly associated with CAC in early CKD, but not in advanced CKD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-021-02463-2. |
format | Online Article Text |
id | pubmed-8255010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82550102021-07-06 Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study Han, Miyeun Kim, Hyunsuk Kim, Hyo Jin Kang, Eunjeong Kim, Yong-Soo Choi, Kyu Hun Kim, Soo Wan Ahn, Curie Oh, Kook-Hwan BMC Nephrol Research BACKGROUND: Although uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known. We evaluated whether UA level is associated with coronary artery calcium (CAC) score in a predialysis CKD cohort. METHODS: A total of 1,350 subjects who underwent coronary computed tomography as part of the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease were analysed. We conducted a logistic regression analysis to evaluate the association between UA and the presence of CAC. RESULTS: CAC was detected in 705 (52.2 %) patients, and the level of UA was significantly higher in CAC > 0 patients. UA showed a positive relationship with CAC > 0 in age- and sex-adjusted logistic regression analysis (Odds ratio (OR) 1.11, 95 % confidence interval (CI) 1.04–1.19, P = 0.003). However, UA showed no association with CAC > 0 in multivariate analysis. Further analysis showed that UA showed a positive association with CAC > 0 only in estimated glomerual filtration rate (eGFR) > 60 ml/min/1.73 m(2) (OR 1.23, 95 % CI 1.02–1.49, P = 0.036) but not in eGFR 30–59 ml/min/1.73 m(2) (OR 0.92, 95 % CI 0.78–1.08, P = 0.309) or < 30 ml/min/1.73 m(2) (OR 0.92, 95 % CI 0.79–1.08, P = 0.426). CONCLUSIONS: UA level was significantly associated with CAC in early CKD, but not in advanced CKD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-021-02463-2. BioMed Central 2021-07-04 /pmc/articles/PMC8255010/ /pubmed/34218791 http://dx.doi.org/10.1186/s12882-021-02463-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Han, Miyeun Kim, Hyunsuk Kim, Hyo Jin Kang, Eunjeong Kim, Yong-Soo Choi, Kyu Hun Kim, Soo Wan Ahn, Curie Oh, Kook-Hwan Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study |
title | Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study |
title_full | Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study |
title_fullStr | Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study |
title_full_unstemmed | Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study |
title_short | Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study |
title_sort | serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255010/ https://www.ncbi.nlm.nih.gov/pubmed/34218791 http://dx.doi.org/10.1186/s12882-021-02463-2 |
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