Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids

BACKGROUND: Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) stiffness activates mechanical signaling and Hippo/YAP promoting fibroid growth, but no prior studies have tested e...

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Detalles Bibliográficos
Autores principales: Islam, Md Soriful, Afrin, Sadia, Singh, Bhuchitra, Jayes, Friederike L., Brennan, Joshua T., Borahay, Mostafa A., Leppert, Phyllis C., Segars, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255059/
https://www.ncbi.nlm.nih.gov/pubmed/34323413
http://dx.doi.org/10.1002/ctm2.475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255059/
https://www.ncbi.nlm.nih.gov/pubmed/34323413
http://dx.doi.org/10.1002/ctm2.475

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