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Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids
BACKGROUND: Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) stiffness activates mechanical signaling and Hippo/YAP promoting fibroid growth, but no prior studies have tested e...
Autores principales: | Islam, Md Soriful, Afrin, Sadia, Singh, Bhuchitra, Jayes, Friederike L., Brennan, Joshua T., Borahay, Mostafa A., Leppert, Phyllis C., Segars, James H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255059/ https://www.ncbi.nlm.nih.gov/pubmed/34323413 http://dx.doi.org/10.1002/ctm2.475 |
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