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Is Mucormycosis an inevitable complication of Covid-19 in India?

Mucormycosis or black fungus infection is a less common disease but highly fatal infection, infecting the immunocompromised individuals. The site of predilection of the fungus is found to be lungs and brain in addition to its sequestration in sinusoidal spaces. Presently with the ongoing COVID 19 pa...

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Autores principales: Bhogireddy, Ramadevi, Krishnamurthy, Venkataraman, Jabaris S, Sugin Lal, Pullaiah, Chitikela P, Manohar, Swetha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255098/
https://www.ncbi.nlm.nih.gov/pubmed/34289382
http://dx.doi.org/10.1016/j.bjid.2021.101597
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author Bhogireddy, Ramadevi
Krishnamurthy, Venkataraman
Jabaris S, Sugin Lal
Pullaiah, Chitikela P
Manohar, Swetha
author_facet Bhogireddy, Ramadevi
Krishnamurthy, Venkataraman
Jabaris S, Sugin Lal
Pullaiah, Chitikela P
Manohar, Swetha
author_sort Bhogireddy, Ramadevi
collection PubMed
description Mucormycosis or black fungus infection is a less common disease but highly fatal infection, infecting the immunocompromised individuals. The site of predilection of the fungus is found to be lungs and brain in addition to its sequestration in sinusoidal spaces. Presently with the ongoing COVID 19 pandemic, the prevalence of this infection is found to be high in the Indian population. The fungus establishes itself by affecting the compromised immune system of an individual and thereby making the individual susceptible to other diseases/infection. The reasons attributed to the sudden upsurge are steroidal therapeutics abuse, tocilizumab therapy and diabetes mellitus.To avert the cytokine storm, the medical health workers are necessitated to include steroid drugs in COVID 19 treatment protocol however inclusion of these drugs in patients who do essentially require steroids can have their immune system debilitated and permit the invasion of this fungus. According to International Diabetes Federation (IDF), 77 million Indians are known to be diabetic, cautioning the physicians to be vigilante of the impending black fungus infection in the event of COVID19 affliction in such individuals. There is causal relationship between anti-hyperglycemic drugs and weakened immune system and opportunity for the fungus invasion. This review attempts to explain the inter-relatedness of COVID19 infection, its treatment and eventual black fungus infection risk.
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spelling pubmed-82550982021-07-06 Is Mucormycosis an inevitable complication of Covid-19 in India? Bhogireddy, Ramadevi Krishnamurthy, Venkataraman Jabaris S, Sugin Lal Pullaiah, Chitikela P Manohar, Swetha Braz J Infect Dis Brief Communication Mucormycosis or black fungus infection is a less common disease but highly fatal infection, infecting the immunocompromised individuals. The site of predilection of the fungus is found to be lungs and brain in addition to its sequestration in sinusoidal spaces. Presently with the ongoing COVID 19 pandemic, the prevalence of this infection is found to be high in the Indian population. The fungus establishes itself by affecting the compromised immune system of an individual and thereby making the individual susceptible to other diseases/infection. The reasons attributed to the sudden upsurge are steroidal therapeutics abuse, tocilizumab therapy and diabetes mellitus.To avert the cytokine storm, the medical health workers are necessitated to include steroid drugs in COVID 19 treatment protocol however inclusion of these drugs in patients who do essentially require steroids can have their immune system debilitated and permit the invasion of this fungus. According to International Diabetes Federation (IDF), 77 million Indians are known to be diabetic, cautioning the physicians to be vigilante of the impending black fungus infection in the event of COVID19 affliction in such individuals. There is causal relationship between anti-hyperglycemic drugs and weakened immune system and opportunity for the fungus invasion. This review attempts to explain the inter-relatedness of COVID19 infection, its treatment and eventual black fungus infection risk. Elsevier 2021-07-05 /pmc/articles/PMC8255098/ /pubmed/34289382 http://dx.doi.org/10.1016/j.bjid.2021.101597 Text en © 2021 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Brief Communication
Bhogireddy, Ramadevi
Krishnamurthy, Venkataraman
Jabaris S, Sugin Lal
Pullaiah, Chitikela P
Manohar, Swetha
Is Mucormycosis an inevitable complication of Covid-19 in India?
title Is Mucormycosis an inevitable complication of Covid-19 in India?
title_full Is Mucormycosis an inevitable complication of Covid-19 in India?
title_fullStr Is Mucormycosis an inevitable complication of Covid-19 in India?
title_full_unstemmed Is Mucormycosis an inevitable complication of Covid-19 in India?
title_short Is Mucormycosis an inevitable complication of Covid-19 in India?
title_sort is mucormycosis an inevitable complication of covid-19 in india?
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255098/
https://www.ncbi.nlm.nih.gov/pubmed/34289382
http://dx.doi.org/10.1016/j.bjid.2021.101597
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