Proteomic analysis identifies key differences in the cardiac interactomes of dystrophin and micro-dystrophin

ΔR4-R23/ΔCT micro-dystrophin (μDys) is a miniaturized version of dystrophin currently evaluated in a Duchenne muscular dystrophy (DMD) gene therapy trial to treat skeletal and cardiac muscle disease. In pre-clinical studies, μDys efficiently rescues cardiac histopathology, but only partially normali...

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Detalles Bibliográficos
Autores principales: Wang, Hong, Marrosu, Elena, Brayson, Daniel, Wasala, Nalinda B, Johnson, Eric K, Scott, Charlotte S, Yue, Yongping, Hau, Kwan-Leong, Trask, Aaron J, Froehner, Stan C, Adams, Marvin E, Zhang, Liwen, Duan, Dongsheng, Montanaro, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255133/
https://www.ncbi.nlm.nih.gov/pubmed/33949649
http://dx.doi.org/10.1093/hmg/ddab133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255133/
https://www.ncbi.nlm.nih.gov/pubmed/33949649
http://dx.doi.org/10.1093/hmg/ddab133

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