Structural Requirements for Modulating 4-Benzylpiperidine Carboxamides from Serotonin/Norepinephrine Reuptake Inhibitors to Triple Reuptake Inhibitors

In this study, we determined the effect of 24 different synthetic 4-benzylpiperidine carboxamides on the reuptake of serotonin, norepinephrine, and dopamine (DA), and characterized their structure–activity relationship. The compounds with a two-carbon linker inhibited DA reuptake with much higher po...

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Detalles Bibliográficos
Autores principales: Paudel, Suresh, Kim, Eunae, Zhu, Anlin, Acharya, Srijan, Min, Xiao, Cheon, Seung Hoon, Kim, Kyeong-Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255136/
https://www.ncbi.nlm.nih.gov/pubmed/34053940
http://dx.doi.org/10.4062/biomolther.2020.233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255136/
https://www.ncbi.nlm.nih.gov/pubmed/34053940
http://dx.doi.org/10.4062/biomolther.2020.233

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