SARS-CoV-2 N gene mutations impact detection by clinical molecular diagnostics: reports in two cities in the United States

Nasal and nasopharyngeal swab specimens tested by the Cepheid Xpert Xpress SARS-CoV-2 were analyzed by whole-genome sequencing based on impaired detection of the N2 target. Each viral genome had at least one mutation in the N gene, which likely arose independently in the New York City and Pittsburgh...

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Detalles Bibliográficos
Autores principales: Leelawong, Mindy, Mitchell, Stephanie L., Fowler, Randal C., Gonzalez, Edimarlyn, Hughes, Scott, Griffith, Marissa P., Marsh, Jane W., Harrison, Lee H., Rakeman, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255188/
https://www.ncbi.nlm.nih.gov/pubmed/34425451
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115468
Descripción
Sumario:Nasal and nasopharyngeal swab specimens tested by the Cepheid Xpert Xpress SARS-CoV-2 were analyzed by whole-genome sequencing based on impaired detection of the N2 target. Each viral genome had at least one mutation in the N gene, which likely arose independently in the New York City and Pittsburgh study sites.

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