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Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers
Microanatomy of the vast majority of human organs at birth is characterized by marked differences as compared to adult organs, regarding their architecture and the cell types detectable at histology. In preterm neonates, these differences are even more evident, due to the lower level of organ matura...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255250/ https://www.ncbi.nlm.nih.gov/pubmed/34219203 http://dx.doi.org/10.1186/s13619-021-00084-6 |
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author | Fanni, D. Gerosa, C. Loddo, C. Castagnola, M. Fanos, V. Zaffanello, M. Faa, G. |
author_facet | Fanni, D. Gerosa, C. Loddo, C. Castagnola, M. Fanos, V. Zaffanello, M. Faa, G. |
author_sort | Fanni, D. |
collection | PubMed |
description | Microanatomy of the vast majority of human organs at birth is characterized by marked differences as compared to adult organs, regarding their architecture and the cell types detectable at histology. In preterm neonates, these differences are even more evident, due to the lower level of organ maturation and to ongoing cell differentiation. One of the most remarkable finding in preterm tissues is the presence of huge amounts of stem/progenitor cells in multiple organs, including kidney, brain, heart, adrenals, and lungs. In other organs, such as liver, the completely different burden of cell types in preterm infants is mainly related to the different function of the liver during gestation, mainly focused on hematopoiesis, a function that is taken by bone marrow after birth. Our preliminary studies showed that the antigens expressed by stem/progenitors differ significantly from one organ to the next. Moreover, within each developing human tissue, reactivity for different stem cell markers also changes during gestation, according with the multiple differentiation steps encountered by each progenitor during development. A better knowledge of stem/progenitor cells of preterms will allow neonatologists to boost preterm organ maturation, favoring the differentiation of the multiple cells types that characterize each organ in at term neonates. |
format | Online Article Text |
id | pubmed-8255250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-82552502021-07-23 Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers Fanni, D. Gerosa, C. Loddo, C. Castagnola, M. Fanos, V. Zaffanello, M. Faa, G. Cell Regen Review Microanatomy of the vast majority of human organs at birth is characterized by marked differences as compared to adult organs, regarding their architecture and the cell types detectable at histology. In preterm neonates, these differences are even more evident, due to the lower level of organ maturation and to ongoing cell differentiation. One of the most remarkable finding in preterm tissues is the presence of huge amounts of stem/progenitor cells in multiple organs, including kidney, brain, heart, adrenals, and lungs. In other organs, such as liver, the completely different burden of cell types in preterm infants is mainly related to the different function of the liver during gestation, mainly focused on hematopoiesis, a function that is taken by bone marrow after birth. Our preliminary studies showed that the antigens expressed by stem/progenitors differ significantly from one organ to the next. Moreover, within each developing human tissue, reactivity for different stem cell markers also changes during gestation, according with the multiple differentiation steps encountered by each progenitor during development. A better knowledge of stem/progenitor cells of preterms will allow neonatologists to boost preterm organ maturation, favoring the differentiation of the multiple cells types that characterize each organ in at term neonates. Springer Singapore 2021-07-05 /pmc/articles/PMC8255250/ /pubmed/34219203 http://dx.doi.org/10.1186/s13619-021-00084-6 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Fanni, D. Gerosa, C. Loddo, C. Castagnola, M. Fanos, V. Zaffanello, M. Faa, G. Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers |
title | Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers |
title_full | Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers |
title_fullStr | Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers |
title_full_unstemmed | Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers |
title_short | Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers |
title_sort | stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255250/ https://www.ncbi.nlm.nih.gov/pubmed/34219203 http://dx.doi.org/10.1186/s13619-021-00084-6 |
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