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Successful treatment of metastatic bladder pleomorphic giant cell carcinoma with pembrolizumab

INTRODUCTION: Bladder pleomorphic giant cell carcinoma is a rare and aggressive malignancy with a poor prognosis. There are no reports of immune checkpoint inhibitors for bladder pleomorphic giant cell carcinoma to date. CASE PRESENTATION: A 72‐year‐old man presented with gross hematuria due to mult...

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Autores principales: Nezu, Kunihisa, Kakoi, Narihiko, Tezuka, Fumiaki, Ota, Shozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255290/
https://www.ncbi.nlm.nih.gov/pubmed/34258526
http://dx.doi.org/10.1002/iju5.12281
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author Nezu, Kunihisa
Kakoi, Narihiko
Tezuka, Fumiaki
Ota, Shozo
author_facet Nezu, Kunihisa
Kakoi, Narihiko
Tezuka, Fumiaki
Ota, Shozo
author_sort Nezu, Kunihisa
collection PubMed
description INTRODUCTION: Bladder pleomorphic giant cell carcinoma is a rare and aggressive malignancy with a poor prognosis. There are no reports of immune checkpoint inhibitors for bladder pleomorphic giant cell carcinoma to date. CASE PRESENTATION: A 72‐year‐old man presented with gross hematuria due to multiple bladder cancers. Despite transurethral bladder resection and intravesical injection of Bacillus Calmette–Guérin, bladder cancer recurred. Nineteen months later, he underwent total cystectomy. Pathological examination revealed bladder giant cell carcinoma. Twenty‐eight months later, pembrolizumab was administered due to para‐aortic lymph node metastasis. Forty‐four months later, the lymph node metastasis disappeared, and pembrolizumab administration was terminated. Fifty‐eight months later, the patient has remained in remission at the time of writing. CONCLUSION: Immune checkpoint inhibitors manifest a therapeutic potential in bladder pleomorphic giant cell carcinoma.
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spelling pubmed-82552902021-07-12 Successful treatment of metastatic bladder pleomorphic giant cell carcinoma with pembrolizumab Nezu, Kunihisa Kakoi, Narihiko Tezuka, Fumiaki Ota, Shozo IJU Case Rep Case Reports INTRODUCTION: Bladder pleomorphic giant cell carcinoma is a rare and aggressive malignancy with a poor prognosis. There are no reports of immune checkpoint inhibitors for bladder pleomorphic giant cell carcinoma to date. CASE PRESENTATION: A 72‐year‐old man presented with gross hematuria due to multiple bladder cancers. Despite transurethral bladder resection and intravesical injection of Bacillus Calmette–Guérin, bladder cancer recurred. Nineteen months later, he underwent total cystectomy. Pathological examination revealed bladder giant cell carcinoma. Twenty‐eight months later, pembrolizumab was administered due to para‐aortic lymph node metastasis. Forty‐four months later, the lymph node metastasis disappeared, and pembrolizumab administration was terminated. Fifty‐eight months later, the patient has remained in remission at the time of writing. CONCLUSION: Immune checkpoint inhibitors manifest a therapeutic potential in bladder pleomorphic giant cell carcinoma. John Wiley and Sons Inc. 2021-03-16 /pmc/articles/PMC8255290/ /pubmed/34258526 http://dx.doi.org/10.1002/iju5.12281 Text en © 2021 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Nezu, Kunihisa
Kakoi, Narihiko
Tezuka, Fumiaki
Ota, Shozo
Successful treatment of metastatic bladder pleomorphic giant cell carcinoma with pembrolizumab
title Successful treatment of metastatic bladder pleomorphic giant cell carcinoma with pembrolizumab
title_full Successful treatment of metastatic bladder pleomorphic giant cell carcinoma with pembrolizumab
title_fullStr Successful treatment of metastatic bladder pleomorphic giant cell carcinoma with pembrolizumab
title_full_unstemmed Successful treatment of metastatic bladder pleomorphic giant cell carcinoma with pembrolizumab
title_short Successful treatment of metastatic bladder pleomorphic giant cell carcinoma with pembrolizumab
title_sort successful treatment of metastatic bladder pleomorphic giant cell carcinoma with pembrolizumab
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255290/
https://www.ncbi.nlm.nih.gov/pubmed/34258526
http://dx.doi.org/10.1002/iju5.12281
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