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Male Breast Cancer: A Comparative Analysis from the National Cancer Database
PURPOSE: Breast cancer (BC) in males accounts for <0.5% of all male cancer diagnoses and ~1% of all BCs in the United States. We sought to describe clinicopathologic characteristics among male and female BC patients and differences in overall survival (OS) through the National Cancer Database ove...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Sexual Medicine and Andrology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255393/ https://www.ncbi.nlm.nih.gov/pubmed/33474851 http://dx.doi.org/10.5534/wjmh.200164 |
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author | Elimimian, Elizabeth B. Elson, Leah Li, Hong Liang, Hong Bilani, Nadeem Zabor, Emily C. Statler, Abby Nahleh, Zeina |
author_facet | Elimimian, Elizabeth B. Elson, Leah Li, Hong Liang, Hong Bilani, Nadeem Zabor, Emily C. Statler, Abby Nahleh, Zeina |
author_sort | Elimimian, Elizabeth B. |
collection | PubMed |
description | PURPOSE: Breast cancer (BC) in males accounts for <0.5% of all male cancer diagnoses and ~1% of all BCs in the United States. We sought to describe clinicopathologic characteristics among male and female BC patients and differences in overall survival (OS) through the National Cancer Database over 13 years (2004–2016). MATERIALS AND METHODS: Secondary to the 1:99 ratio of male to female BC cases, we randomly selected female cases for equal comparison to males cases by diagnosis year. Chi-square and t-tests compared demographic and tumor characteristics. OS was examined using Kaplan–Meier survival analysis. RESULTS: Among the ~2.7 million BC patients, 9 per 1,000 BCs were in males, the rate remained similar over time. The mean (SD) age was 64.9±13.0 years for males and 60.7±13.6 years for females. Most of the male BC cases were white (non-Hispanic) (n=19,015 [80.2%]), clinical stage I (n=7,353 [32.1%]) or stage II disease (n=7,923 [34.6%]), and tumors were moderate or poorly differentiated (84.5%). Males exhibited more comorbidities, presented with a larger proportion of disease, and decreased OS (p<0.005) than females. Male OS was >10% lower at 5-years and nearly 20% lower at 10-years for males. More males had primary BC tumors under the nipple; the 10-year OS rate for this site was 48.8%. CONCLUSIONS: This study reports clinicopathologic characteristics of a large cohort of male BC. Males present at older age, with a greater comorbidity index, at later stages of disease. Increased education regarding the continued risks of male breast cancer may be warranted. |
format | Online Article Text |
id | pubmed-8255393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society for Sexual Medicine and Andrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-82553932021-07-06 Male Breast Cancer: A Comparative Analysis from the National Cancer Database Elimimian, Elizabeth B. Elson, Leah Li, Hong Liang, Hong Bilani, Nadeem Zabor, Emily C. Statler, Abby Nahleh, Zeina World J Mens Health Original Article PURPOSE: Breast cancer (BC) in males accounts for <0.5% of all male cancer diagnoses and ~1% of all BCs in the United States. We sought to describe clinicopathologic characteristics among male and female BC patients and differences in overall survival (OS) through the National Cancer Database over 13 years (2004–2016). MATERIALS AND METHODS: Secondary to the 1:99 ratio of male to female BC cases, we randomly selected female cases for equal comparison to males cases by diagnosis year. Chi-square and t-tests compared demographic and tumor characteristics. OS was examined using Kaplan–Meier survival analysis. RESULTS: Among the ~2.7 million BC patients, 9 per 1,000 BCs were in males, the rate remained similar over time. The mean (SD) age was 64.9±13.0 years for males and 60.7±13.6 years for females. Most of the male BC cases were white (non-Hispanic) (n=19,015 [80.2%]), clinical stage I (n=7,353 [32.1%]) or stage II disease (n=7,923 [34.6%]), and tumors were moderate or poorly differentiated (84.5%). Males exhibited more comorbidities, presented with a larger proportion of disease, and decreased OS (p<0.005) than females. Male OS was >10% lower at 5-years and nearly 20% lower at 10-years for males. More males had primary BC tumors under the nipple; the 10-year OS rate for this site was 48.8%. CONCLUSIONS: This study reports clinicopathologic characteristics of a large cohort of male BC. Males present at older age, with a greater comorbidity index, at later stages of disease. Increased education regarding the continued risks of male breast cancer may be warranted. Korean Society for Sexual Medicine and Andrology 2021-07 2020-12-04 /pmc/articles/PMC8255393/ /pubmed/33474851 http://dx.doi.org/10.5534/wjmh.200164 Text en Copyright © 2021 Korean Society for Sexual Medicine and Andrology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Elimimian, Elizabeth B. Elson, Leah Li, Hong Liang, Hong Bilani, Nadeem Zabor, Emily C. Statler, Abby Nahleh, Zeina Male Breast Cancer: A Comparative Analysis from the National Cancer Database |
title | Male Breast Cancer: A Comparative Analysis from the National Cancer Database |
title_full | Male Breast Cancer: A Comparative Analysis from the National Cancer Database |
title_fullStr | Male Breast Cancer: A Comparative Analysis from the National Cancer Database |
title_full_unstemmed | Male Breast Cancer: A Comparative Analysis from the National Cancer Database |
title_short | Male Breast Cancer: A Comparative Analysis from the National Cancer Database |
title_sort | male breast cancer: a comparative analysis from the national cancer database |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255393/ https://www.ncbi.nlm.nih.gov/pubmed/33474851 http://dx.doi.org/10.5534/wjmh.200164 |
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