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Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo

Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low...

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Autores principales: Zhang, Run-Hui, Jin, Runhao, Deng, Hao, Shen, Qing-Kun, Quan, Zhe-Shan, Jin, Chun-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Parasitology and Tropical Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255499/
https://www.ncbi.nlm.nih.gov/pubmed/34218602
http://dx.doi.org/10.3347/kjp.2021.59.3.297
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author Zhang, Run-Hui
Jin, Runhao
Deng, Hao
Shen, Qing-Kun
Quan, Zhe-Shan
Jin, Chun-Mei
author_facet Zhang, Run-Hui
Jin, Runhao
Deng, Hao
Shen, Qing-Kun
Quan, Zhe-Shan
Jin, Chun-Mei
author_sort Zhang, Run-Hui
collection PubMed
description Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent.
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spelling pubmed-82554992021-07-15 Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo Zhang, Run-Hui Jin, Runhao Deng, Hao Shen, Qing-Kun Quan, Zhe-Shan Jin, Chun-Mei Korean J Parasitol Brief Communication Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent. The Korean Society for Parasitology and Tropical Medicine 2021-06 2021-06-30 /pmc/articles/PMC8255499/ /pubmed/34218602 http://dx.doi.org/10.3347/kjp.2021.59.3.297 Text en © 2021, Korean Society for Parasitology and Tropical Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Zhang, Run-Hui
Jin, Runhao
Deng, Hao
Shen, Qing-Kun
Quan, Zhe-Shan
Jin, Chun-Mei
Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
title Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
title_full Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
title_fullStr Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
title_full_unstemmed Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
title_short Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
title_sort evaluation of the anti-toxoplasma gondii activity of hederagenin in vitro and in vivo
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255499/
https://www.ncbi.nlm.nih.gov/pubmed/34218602
http://dx.doi.org/10.3347/kjp.2021.59.3.297
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