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Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society for Parasitology and Tropical Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255499/ https://www.ncbi.nlm.nih.gov/pubmed/34218602 http://dx.doi.org/10.3347/kjp.2021.59.3.297 |
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author | Zhang, Run-Hui Jin, Runhao Deng, Hao Shen, Qing-Kun Quan, Zhe-Shan Jin, Chun-Mei |
author_facet | Zhang, Run-Hui Jin, Runhao Deng, Hao Shen, Qing-Kun Quan, Zhe-Shan Jin, Chun-Mei |
author_sort | Zhang, Run-Hui |
collection | PubMed |
description | Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent. |
format | Online Article Text |
id | pubmed-8255499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Korean Society for Parasitology and Tropical Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-82554992021-07-15 Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo Zhang, Run-Hui Jin, Runhao Deng, Hao Shen, Qing-Kun Quan, Zhe-Shan Jin, Chun-Mei Korean J Parasitol Brief Communication Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent. The Korean Society for Parasitology and Tropical Medicine 2021-06 2021-06-30 /pmc/articles/PMC8255499/ /pubmed/34218602 http://dx.doi.org/10.3347/kjp.2021.59.3.297 Text en © 2021, Korean Society for Parasitology and Tropical Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Zhang, Run-Hui Jin, Runhao Deng, Hao Shen, Qing-Kun Quan, Zhe-Shan Jin, Chun-Mei Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo |
title | Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo |
title_full | Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo |
title_fullStr | Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo |
title_full_unstemmed | Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo |
title_short | Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo |
title_sort | evaluation of the anti-toxoplasma gondii activity of hederagenin in vitro and in vivo |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255499/ https://www.ncbi.nlm.nih.gov/pubmed/34218602 http://dx.doi.org/10.3347/kjp.2021.59.3.297 |
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