Cargando…
FOXD1 is a prognostic biomarker and correlated with macrophages infiltration in head and neck squamous cell carcinoma
Background: Forkhead Box D1 (FOXD1) is differentially expressed in various tumors. However, its role and correlation with immune cell infiltration remains uncertain in head and neck squamous cell carcinoma (HNSC). Methods: FOXD1 expression was analyzed in The Cancer Genome Atlas (TCGA) pan-cancer da...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255535/ https://www.ncbi.nlm.nih.gov/pubmed/34028536 http://dx.doi.org/10.1042/BSR20202929 |
_version_ | 1783717924747345920 |
---|---|
author | Liang, Huazhen Zhang, Chunning Li, Chaoming Li, Changguo Wang, Yanli Lin, Huaming |
author_facet | Liang, Huazhen Zhang, Chunning Li, Chaoming Li, Changguo Wang, Yanli Lin, Huaming |
author_sort | Liang, Huazhen |
collection | PubMed |
description | Background: Forkhead Box D1 (FOXD1) is differentially expressed in various tumors. However, its role and correlation with immune cell infiltration remains uncertain in head and neck squamous cell carcinoma (HNSC). Methods: FOXD1 expression was analyzed in The Cancer Genome Atlas (TCGA) pan-cancer data. The clinical prognosis influence of FOXD1 was evaluated by clinical survival data of TCGA. Enrichment analysis of FOXD1 was performed using R packages ‘clusterProfiler’. We downloaded the immune cell infiltration score of TCGA samples from published articles, and analyzed the correlation between immune cell infiltration level and FOXD1 expression. Results: FOXD1 was highly expressed and associated with poorer overall survival (OS, P<0.0001), disease-specific survival (DSS, P=0.00011), and progression-free interval (PFI, P<0.0001) in HNSC and some other tumors. In addition, FOXD1 expression was significantly correlated with infiltration of immune cells. Tumor-associated macrophages (TAMs) infiltration increased in tissues with high FOXD1 expression in HNSC. Immunosuppressive genes such as PD-L1, IL-10, TGFB1, and TGFBR1 were significantly positively correlated with FOXD1. Conclusions: Our study suggests FOXD1 to be an oncogene and act as an indicator of poor prognosis in HNSC. FOXD1 might contribute to the TAM infiltration in HNSC. High FOXD1 may be associated with tumor immunosuppression status. |
format | Online Article Text |
id | pubmed-8255535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82555352021-07-16 FOXD1 is a prognostic biomarker and correlated with macrophages infiltration in head and neck squamous cell carcinoma Liang, Huazhen Zhang, Chunning Li, Chaoming Li, Changguo Wang, Yanli Lin, Huaming Biosci Rep Cancer Background: Forkhead Box D1 (FOXD1) is differentially expressed in various tumors. However, its role and correlation with immune cell infiltration remains uncertain in head and neck squamous cell carcinoma (HNSC). Methods: FOXD1 expression was analyzed in The Cancer Genome Atlas (TCGA) pan-cancer data. The clinical prognosis influence of FOXD1 was evaluated by clinical survival data of TCGA. Enrichment analysis of FOXD1 was performed using R packages ‘clusterProfiler’. We downloaded the immune cell infiltration score of TCGA samples from published articles, and analyzed the correlation between immune cell infiltration level and FOXD1 expression. Results: FOXD1 was highly expressed and associated with poorer overall survival (OS, P<0.0001), disease-specific survival (DSS, P=0.00011), and progression-free interval (PFI, P<0.0001) in HNSC and some other tumors. In addition, FOXD1 expression was significantly correlated with infiltration of immune cells. Tumor-associated macrophages (TAMs) infiltration increased in tissues with high FOXD1 expression in HNSC. Immunosuppressive genes such as PD-L1, IL-10, TGFB1, and TGFBR1 were significantly positively correlated with FOXD1. Conclusions: Our study suggests FOXD1 to be an oncogene and act as an indicator of poor prognosis in HNSC. FOXD1 might contribute to the TAM infiltration in HNSC. High FOXD1 may be associated with tumor immunosuppression status. Portland Press Ltd. 2021-07-02 /pmc/articles/PMC8255535/ /pubmed/34028536 http://dx.doi.org/10.1042/BSR20202929 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Cancer Liang, Huazhen Zhang, Chunning Li, Chaoming Li, Changguo Wang, Yanli Lin, Huaming FOXD1 is a prognostic biomarker and correlated with macrophages infiltration in head and neck squamous cell carcinoma |
title | FOXD1 is a prognostic biomarker and correlated with macrophages infiltration in head and neck squamous cell carcinoma |
title_full | FOXD1 is a prognostic biomarker and correlated with macrophages infiltration in head and neck squamous cell carcinoma |
title_fullStr | FOXD1 is a prognostic biomarker and correlated with macrophages infiltration in head and neck squamous cell carcinoma |
title_full_unstemmed | FOXD1 is a prognostic biomarker and correlated with macrophages infiltration in head and neck squamous cell carcinoma |
title_short | FOXD1 is a prognostic biomarker and correlated with macrophages infiltration in head and neck squamous cell carcinoma |
title_sort | foxd1 is a prognostic biomarker and correlated with macrophages infiltration in head and neck squamous cell carcinoma |
topic | Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255535/ https://www.ncbi.nlm.nih.gov/pubmed/34028536 http://dx.doi.org/10.1042/BSR20202929 |
work_keys_str_mv | AT lianghuazhen foxd1isaprognosticbiomarkerandcorrelatedwithmacrophagesinfiltrationinheadandnecksquamouscellcarcinoma AT zhangchunning foxd1isaprognosticbiomarkerandcorrelatedwithmacrophagesinfiltrationinheadandnecksquamouscellcarcinoma AT lichaoming foxd1isaprognosticbiomarkerandcorrelatedwithmacrophagesinfiltrationinheadandnecksquamouscellcarcinoma AT lichangguo foxd1isaprognosticbiomarkerandcorrelatedwithmacrophagesinfiltrationinheadandnecksquamouscellcarcinoma AT wangyanli foxd1isaprognosticbiomarkerandcorrelatedwithmacrophagesinfiltrationinheadandnecksquamouscellcarcinoma AT linhuaming foxd1isaprognosticbiomarkerandcorrelatedwithmacrophagesinfiltrationinheadandnecksquamouscellcarcinoma |