Cargando…
Statin-Induced Autoimmune Necrotizing Myopathy
Statin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the production of cholesterol. As a re...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255573/ https://www.ncbi.nlm.nih.gov/pubmed/34219515 http://dx.doi.org/10.1177/21501327211028714 |
_version_ | 1783717933501906944 |
---|---|
author | Jayatilaka, Sahani Desai, Kunal Rijal, Swarup Zimmerman, Debra |
author_facet | Jayatilaka, Sahani Desai, Kunal Rijal, Swarup Zimmerman, Debra |
author_sort | Jayatilaka, Sahani |
collection | PubMed |
description | Statin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the production of cholesterol. As a result, an autoimmune reaction causing weakness, myalgia, with possible severe rhabdomyolysis, renal failure, and myonecrosis also can occur. A 73-year-old female presented to clinic with myalgia and fatigue. She was on atorvastatin 20 mg/day for over 1 year, which she stopped 1 week prior to her initial presentation. Patient did experience rhabdomyolysis as well as a transaminitis. She underwent an autoimmune workup which was positive for HMG-CoA reductase antibodies. Patient was initially treated on a prednisone taper, starting dose 50 mg/day. Without remission of symptoms, methotrexate 15 mg/week was initiated. |
format | Online Article Text |
id | pubmed-8255573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-82555732021-07-16 Statin-Induced Autoimmune Necrotizing Myopathy Jayatilaka, Sahani Desai, Kunal Rijal, Swarup Zimmerman, Debra J Prim Care Community Health Case Studies Statin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the production of cholesterol. As a result, an autoimmune reaction causing weakness, myalgia, with possible severe rhabdomyolysis, renal failure, and myonecrosis also can occur. A 73-year-old female presented to clinic with myalgia and fatigue. She was on atorvastatin 20 mg/day for over 1 year, which she stopped 1 week prior to her initial presentation. Patient did experience rhabdomyolysis as well as a transaminitis. She underwent an autoimmune workup which was positive for HMG-CoA reductase antibodies. Patient was initially treated on a prednisone taper, starting dose 50 mg/day. Without remission of symptoms, methotrexate 15 mg/week was initiated. SAGE Publications 2021-07-03 /pmc/articles/PMC8255573/ /pubmed/34219515 http://dx.doi.org/10.1177/21501327211028714 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Studies Jayatilaka, Sahani Desai, Kunal Rijal, Swarup Zimmerman, Debra Statin-Induced Autoimmune Necrotizing Myopathy |
title | Statin-Induced Autoimmune Necrotizing Myopathy |
title_full | Statin-Induced Autoimmune Necrotizing Myopathy |
title_fullStr | Statin-Induced Autoimmune Necrotizing Myopathy |
title_full_unstemmed | Statin-Induced Autoimmune Necrotizing Myopathy |
title_short | Statin-Induced Autoimmune Necrotizing Myopathy |
title_sort | statin-induced autoimmune necrotizing myopathy |
topic | Case Studies |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255573/ https://www.ncbi.nlm.nih.gov/pubmed/34219515 http://dx.doi.org/10.1177/21501327211028714 |
work_keys_str_mv | AT jayatilakasahani statininducedautoimmunenecrotizingmyopathy AT desaikunal statininducedautoimmunenecrotizingmyopathy AT rijalswarup statininducedautoimmunenecrotizingmyopathy AT zimmermandebra statininducedautoimmunenecrotizingmyopathy |