Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures

Background: Baicalin (BCL), a candidate drug for ischemic stroke, has been indicated to protect neurons by promoting brain-derived neurotrophic factor (BDNF). However, the cellular source of BDNF release promoted by baicalin and its detailed protective mechanism after ischemia/reperfusion remains to...

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Detalles Bibliográficos
Autores principales: Li, Changxiang, Sui, Conglu, Wang, Wei, Yan, Juntang, Deng, Nan, Du, Xin, Cheng, Fafeng, Ma, Xiaona, Wang, Xueqian, Wang, Qingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255628/
https://www.ncbi.nlm.nih.gov/pubmed/34234667
http://dx.doi.org/10.3389/fphar.2021.599543

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