Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer

We report the case of a 54-year-old man who was treated with nivolumab for recurrent squamous cell lung cancer. After 7 cycles of nivolumab treatment, the patient presented to our hospital with right eye vision loss. Gadolinium-enhanced magnetic resonance imaging of the brain showed enhancement arou...

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Autores principales: Takada, Kenji, Fujiwara, Keiichi, Ando, Eri, Onishi, Kiriko, Kuribayashi, Tadahiro, Mitsumune, Sho, Takigawa, Yuki, Matsuura, Hiroaki, Watanabe, Hiromi, Kudo, Kenichiro, Sato, Akiko, Sato, Ken, Shibayama, Takuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255753/
https://www.ncbi.nlm.nih.gov/pubmed/34248541
http://dx.doi.org/10.1159/000516275
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author Takada, Kenji
Fujiwara, Keiichi
Ando, Eri
Onishi, Kiriko
Kuribayashi, Tadahiro
Mitsumune, Sho
Takigawa, Yuki
Matsuura, Hiroaki
Watanabe, Hiromi
Kudo, Kenichiro
Sato, Akiko
Sato, Ken
Shibayama, Takuo
author_facet Takada, Kenji
Fujiwara, Keiichi
Ando, Eri
Onishi, Kiriko
Kuribayashi, Tadahiro
Mitsumune, Sho
Takigawa, Yuki
Matsuura, Hiroaki
Watanabe, Hiromi
Kudo, Kenichiro
Sato, Akiko
Sato, Ken
Shibayama, Takuo
author_sort Takada, Kenji
collection PubMed
description We report the case of a 54-year-old man who was treated with nivolumab for recurrent squamous cell lung cancer. After 7 cycles of nivolumab treatment, the patient presented to our hospital with right eye vision loss. Gadolinium-enhanced magnetic resonance imaging of the brain showed enhancement around the optic nerve sheath. This finding and his symptoms led to the diagnosis of optic perineuritis (OPN). Steroid pulse therapy was administered twice although there was no remarkable improvement in his visual field defect. The relationship between OPN and nivolumab is unclear. However, immune-related adverse events caused by immune checkpoint inhibitors should be considered.
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spelling pubmed-82557532021-07-09 Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer Takada, Kenji Fujiwara, Keiichi Ando, Eri Onishi, Kiriko Kuribayashi, Tadahiro Mitsumune, Sho Takigawa, Yuki Matsuura, Hiroaki Watanabe, Hiromi Kudo, Kenichiro Sato, Akiko Sato, Ken Shibayama, Takuo Case Rep Oncol Case Report We report the case of a 54-year-old man who was treated with nivolumab for recurrent squamous cell lung cancer. After 7 cycles of nivolumab treatment, the patient presented to our hospital with right eye vision loss. Gadolinium-enhanced magnetic resonance imaging of the brain showed enhancement around the optic nerve sheath. This finding and his symptoms led to the diagnosis of optic perineuritis (OPN). Steroid pulse therapy was administered twice although there was no remarkable improvement in his visual field defect. The relationship between OPN and nivolumab is unclear. However, immune-related adverse events caused by immune checkpoint inhibitors should be considered. S. Karger AG 2021-06-09 /pmc/articles/PMC8255753/ /pubmed/34248541 http://dx.doi.org/10.1159/000516275 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Takada, Kenji
Fujiwara, Keiichi
Ando, Eri
Onishi, Kiriko
Kuribayashi, Tadahiro
Mitsumune, Sho
Takigawa, Yuki
Matsuura, Hiroaki
Watanabe, Hiromi
Kudo, Kenichiro
Sato, Akiko
Sato, Ken
Shibayama, Takuo
Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer
title Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer
title_full Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer
title_fullStr Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer
title_full_unstemmed Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer
title_short Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer
title_sort optic perineuritis associated with nivolumab treatment for non-small cell lung cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255753/
https://www.ncbi.nlm.nih.gov/pubmed/34248541
http://dx.doi.org/10.1159/000516275
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