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Subclinical hypothyroidism in children: updates for pediatricians

Subclinical hypothyroidism (SH) is defined as serum thyroid-stimulating hormone (TSH) above the upper limit of the reference range in the presence of normal free T4 concentrations. Depending on the degree of TSH elevation, SH could be defined as mild (TSH, 4.5–10 mIU/L) or severe (TSH>10 mIU/L)....

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Detalles Bibliográficos
Autores principales: Metwalley, Kotb Abbass, Farghaly, Hekma Saad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Pediatric Endocrinology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255859/
https://www.ncbi.nlm.nih.gov/pubmed/34218629
http://dx.doi.org/10.6065/apem.2040242.121
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author Metwalley, Kotb Abbass
Farghaly, Hekma Saad
author_facet Metwalley, Kotb Abbass
Farghaly, Hekma Saad
author_sort Metwalley, Kotb Abbass
collection PubMed
description Subclinical hypothyroidism (SH) is defined as serum thyroid-stimulating hormone (TSH) above the upper limit of the reference range in the presence of normal free T4 concentrations. Depending on the degree of TSH elevation, SH could be defined as mild (TSH, 4.5–10 mIU/L) or severe (TSH>10 mIU/L). While there is a general consensus to treat children with serum TSH levels above 10 mU/L, the management of the mild form is uncertain and should be individualized. In this mini-review, we present a brief review of SH in children based on extensive literature review and long-standing clinical experience. This review provides the prevalence, causes, clinical presentation, consequences, investigation, and up-to-date therapeutic approach of SH in children. Generally, the purpose of the review is to provide pediatricians with an update of this common and continuously evolving condition.
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spelling pubmed-82558592021-07-15 Subclinical hypothyroidism in children: updates for pediatricians Metwalley, Kotb Abbass Farghaly, Hekma Saad Ann Pediatr Endocrinol Metab Review Article Subclinical hypothyroidism (SH) is defined as serum thyroid-stimulating hormone (TSH) above the upper limit of the reference range in the presence of normal free T4 concentrations. Depending on the degree of TSH elevation, SH could be defined as mild (TSH, 4.5–10 mIU/L) or severe (TSH>10 mIU/L). While there is a general consensus to treat children with serum TSH levels above 10 mU/L, the management of the mild form is uncertain and should be individualized. In this mini-review, we present a brief review of SH in children based on extensive literature review and long-standing clinical experience. This review provides the prevalence, causes, clinical presentation, consequences, investigation, and up-to-date therapeutic approach of SH in children. Generally, the purpose of the review is to provide pediatricians with an update of this common and continuously evolving condition. Korean Society of Pediatric Endocrinology 2021-06 2021-06-30 /pmc/articles/PMC8255859/ /pubmed/34218629 http://dx.doi.org/10.6065/apem.2040242.121 Text en © 2021 Annals of Pediatric Endocrinology & Metabolism https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Metwalley, Kotb Abbass
Farghaly, Hekma Saad
Subclinical hypothyroidism in children: updates for pediatricians
title Subclinical hypothyroidism in children: updates for pediatricians
title_full Subclinical hypothyroidism in children: updates for pediatricians
title_fullStr Subclinical hypothyroidism in children: updates for pediatricians
title_full_unstemmed Subclinical hypothyroidism in children: updates for pediatricians
title_short Subclinical hypothyroidism in children: updates for pediatricians
title_sort subclinical hypothyroidism in children: updates for pediatricians
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255859/
https://www.ncbi.nlm.nih.gov/pubmed/34218629
http://dx.doi.org/10.6065/apem.2040242.121
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