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Multi-omics integration strategies for animal epigenetic studies — A review

Genome-wide studies provide considerable insights into the genetic background of animals; however, the inheritance of several heritable factors cannot be elucidated. Epigenetics explains these heritabilities, including those of genes influenced by environmental factors. Knowledge of the mechanisms u...

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Autores principales: Kim, Do-Young, Kim, Jun-Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Animal Bioscience 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255897/
https://www.ncbi.nlm.nih.gov/pubmed/33902167
http://dx.doi.org/10.5713/ab.21.0042
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author Kim, Do-Young
Kim, Jun-Mo
author_facet Kim, Do-Young
Kim, Jun-Mo
author_sort Kim, Do-Young
collection PubMed
description Genome-wide studies provide considerable insights into the genetic background of animals; however, the inheritance of several heritable factors cannot be elucidated. Epigenetics explains these heritabilities, including those of genes influenced by environmental factors. Knowledge of the mechanisms underlying epigenetics enables understanding the processes of gene regulation through interactions with the environment. Recently developed next-generation sequencing (NGS) technologies help understand the interactional changes in epigenetic mechanisms. There are large sets of NGS data available; however, the integrative data analysis approaches still have limitations with regard to reliably interpreting the epigenetic changes. This review focuses on the epigenetic mechanisms and profiling methods and multi-omics integration methods that can provide comprehensive biological insights in animal genetic studies.
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spelling pubmed-82558972021-08-01 Multi-omics integration strategies for animal epigenetic studies — A review Kim, Do-Young Kim, Jun-Mo Anim Biosci Review Paper Genome-wide studies provide considerable insights into the genetic background of animals; however, the inheritance of several heritable factors cannot be elucidated. Epigenetics explains these heritabilities, including those of genes influenced by environmental factors. Knowledge of the mechanisms underlying epigenetics enables understanding the processes of gene regulation through interactions with the environment. Recently developed next-generation sequencing (NGS) technologies help understand the interactional changes in epigenetic mechanisms. There are large sets of NGS data available; however, the integrative data analysis approaches still have limitations with regard to reliably interpreting the epigenetic changes. This review focuses on the epigenetic mechanisms and profiling methods and multi-omics integration methods that can provide comprehensive biological insights in animal genetic studies. Animal Bioscience 2021-08 2021-04-23 /pmc/articles/PMC8255897/ /pubmed/33902167 http://dx.doi.org/10.5713/ab.21.0042 Text en Copyright © 2021 by Animal Bioscience https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Paper
Kim, Do-Young
Kim, Jun-Mo
Multi-omics integration strategies for animal epigenetic studies — A review
title Multi-omics integration strategies for animal epigenetic studies — A review
title_full Multi-omics integration strategies for animal epigenetic studies — A review
title_fullStr Multi-omics integration strategies for animal epigenetic studies — A review
title_full_unstemmed Multi-omics integration strategies for animal epigenetic studies — A review
title_short Multi-omics integration strategies for animal epigenetic studies — A review
title_sort multi-omics integration strategies for animal epigenetic studies — a review
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255897/
https://www.ncbi.nlm.nih.gov/pubmed/33902167
http://dx.doi.org/10.5713/ab.21.0042
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