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An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures
This article includes a general overview of the published research on a topic relevant to biomedical sciences research, pharma-industries and healthcare sector. We have presented a concise information on three enzymes. These biomolecules have been investigated for their biocatalytic activities benef...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIMS Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255904/ https://www.ncbi.nlm.nih.gov/pubmed/34250371 http://dx.doi.org/10.3934/microbiol.2021009 |
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author | Dahiya, Divakar Nigam, Poonam Singh |
author_facet | Dahiya, Divakar Nigam, Poonam Singh |
author_sort | Dahiya, Divakar |
collection | PubMed |
description | This article includes a general overview of the published research on a topic relevant to biomedical sciences research, pharma-industries and healthcare sector. We have presented a concise information on three enzymes. These biomolecules have been investigated for their biocatalytic activities beneficial in the detection of drugs and their metabolites present in micro-quantities in samples of blood, urine, and other body fluids, such as salicylate hydroxylase, and dihydrofolate reductase. Some enzymes are useful in biotransformation of compounds to convert them in an optically active form, such as lipase. The information presented in this article has been collected from the published studies on their catalytic function, and biosynthesis using selected microorganisms. Several diagnostic assays are currently using enzymes as effective biocatalysts to perform the detection-test. For the marketing and consumer's convenience, pharmaceutical companies have designed biosensors and diagnostic kits by incorporating specific enzymes for rapid tests required in pathology, as well as for the quantification of certain metabolites and chemicals in pathology samples in a shorter time. For such purpose use of enzymes synthesized by selected specific microorganisms is economical. |
format | Online Article Text |
id | pubmed-8255904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AIMS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-82559042021-07-09 An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures Dahiya, Divakar Nigam, Poonam Singh AIMS Microbiol Review This article includes a general overview of the published research on a topic relevant to biomedical sciences research, pharma-industries and healthcare sector. We have presented a concise information on three enzymes. These biomolecules have been investigated for their biocatalytic activities beneficial in the detection of drugs and their metabolites present in micro-quantities in samples of blood, urine, and other body fluids, such as salicylate hydroxylase, and dihydrofolate reductase. Some enzymes are useful in biotransformation of compounds to convert them in an optically active form, such as lipase. The information presented in this article has been collected from the published studies on their catalytic function, and biosynthesis using selected microorganisms. Several diagnostic assays are currently using enzymes as effective biocatalysts to perform the detection-test. For the marketing and consumer's convenience, pharmaceutical companies have designed biosensors and diagnostic kits by incorporating specific enzymes for rapid tests required in pathology, as well as for the quantification of certain metabolites and chemicals in pathology samples in a shorter time. For such purpose use of enzymes synthesized by selected specific microorganisms is economical. AIMS Press 2021-04-27 /pmc/articles/PMC8255904/ /pubmed/34250371 http://dx.doi.org/10.3934/microbiol.2021009 Text en © 2021 the Author(s), licensee AIMS Press https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ) |
spellingShingle | Review Dahiya, Divakar Nigam, Poonam Singh An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures |
title | An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures |
title_full | An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures |
title_fullStr | An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures |
title_full_unstemmed | An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures |
title_short | An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures |
title_sort | overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255904/ https://www.ncbi.nlm.nih.gov/pubmed/34250371 http://dx.doi.org/10.3934/microbiol.2021009 |
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