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An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures

This article includes a general overview of the published research on a topic relevant to biomedical sciences research, pharma-industries and healthcare sector. We have presented a concise information on three enzymes. These biomolecules have been investigated for their biocatalytic activities benef...

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Detalles Bibliográficos
Autores principales: Dahiya, Divakar, Nigam, Poonam Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIMS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255904/
https://www.ncbi.nlm.nih.gov/pubmed/34250371
http://dx.doi.org/10.3934/microbiol.2021009
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author Dahiya, Divakar
Nigam, Poonam Singh
author_facet Dahiya, Divakar
Nigam, Poonam Singh
author_sort Dahiya, Divakar
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description This article includes a general overview of the published research on a topic relevant to biomedical sciences research, pharma-industries and healthcare sector. We have presented a concise information on three enzymes. These biomolecules have been investigated for their biocatalytic activities beneficial in the detection of drugs and their metabolites present in micro-quantities in samples of blood, urine, and other body fluids, such as salicylate hydroxylase, and dihydrofolate reductase. Some enzymes are useful in biotransformation of compounds to convert them in an optically active form, such as lipase. The information presented in this article has been collected from the published studies on their catalytic function, and biosynthesis using selected microorganisms. Several diagnostic assays are currently using enzymes as effective biocatalysts to perform the detection-test. For the marketing and consumer's convenience, pharmaceutical companies have designed biosensors and diagnostic kits by incorporating specific enzymes for rapid tests required in pathology, as well as for the quantification of certain metabolites and chemicals in pathology samples in a shorter time. For such purpose use of enzymes synthesized by selected specific microorganisms is economical.
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spelling pubmed-82559042021-07-09 An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures Dahiya, Divakar Nigam, Poonam Singh AIMS Microbiol Review This article includes a general overview of the published research on a topic relevant to biomedical sciences research, pharma-industries and healthcare sector. We have presented a concise information on three enzymes. These biomolecules have been investigated for their biocatalytic activities beneficial in the detection of drugs and their metabolites present in micro-quantities in samples of blood, urine, and other body fluids, such as salicylate hydroxylase, and dihydrofolate reductase. Some enzymes are useful in biotransformation of compounds to convert them in an optically active form, such as lipase. The information presented in this article has been collected from the published studies on their catalytic function, and biosynthesis using selected microorganisms. Several diagnostic assays are currently using enzymes as effective biocatalysts to perform the detection-test. For the marketing and consumer's convenience, pharmaceutical companies have designed biosensors and diagnostic kits by incorporating specific enzymes for rapid tests required in pathology, as well as for the quantification of certain metabolites and chemicals in pathology samples in a shorter time. For such purpose use of enzymes synthesized by selected specific microorganisms is economical. AIMS Press 2021-04-27 /pmc/articles/PMC8255904/ /pubmed/34250371 http://dx.doi.org/10.3934/microbiol.2021009 Text en © 2021 the Author(s), licensee AIMS Press https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) )
spellingShingle Review
Dahiya, Divakar
Nigam, Poonam Singh
An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures
title An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures
title_full An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures
title_fullStr An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures
title_full_unstemmed An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures
title_short An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures
title_sort overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255904/
https://www.ncbi.nlm.nih.gov/pubmed/34250371
http://dx.doi.org/10.3934/microbiol.2021009
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