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Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition

Non-small cell lung cancer (NSCLC) has the highest morbidity and mortality among all carcinomas. However, it is difficult to diagnose in the early stage, and current therapeutic efficacy is not ideal. Although numerous studies have revealed that Ailanthone (Aila), a natural product, can inhibit mult...

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Autores principales: Chen, Lin, Wu, Cui, Wang, Heming, Chen, Sinuo, Ma, Danhui, Tao, Ye, Wang, Xingye, Luan, Yanhe, Wang, Tiedong, Shi, Yan, Song, Guangqi, Zhao, Yicheng, Dong, Xijun, Wang, Bingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255921/
https://www.ncbi.nlm.nih.gov/pubmed/34235076
http://dx.doi.org/10.3389/fonc.2021.652567
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author Chen, Lin
Wu, Cui
Wang, Heming
Chen, Sinuo
Ma, Danhui
Tao, Ye
Wang, Xingye
Luan, Yanhe
Wang, Tiedong
Shi, Yan
Song, Guangqi
Zhao, Yicheng
Dong, Xijun
Wang, Bingmei
author_facet Chen, Lin
Wu, Cui
Wang, Heming
Chen, Sinuo
Ma, Danhui
Tao, Ye
Wang, Xingye
Luan, Yanhe
Wang, Tiedong
Shi, Yan
Song, Guangqi
Zhao, Yicheng
Dong, Xijun
Wang, Bingmei
author_sort Chen, Lin
collection PubMed
description Non-small cell lung cancer (NSCLC) has the highest morbidity and mortality among all carcinomas. However, it is difficult to diagnose in the early stage, and current therapeutic efficacy is not ideal. Although numerous studies have revealed that Ailanthone (Aila), a natural product, can inhibit multiple cancers by reducing cell proliferation and invasion and inducing apoptosis, the mechanism by which Aila represses NSCLC progression in a time-dependent manner remains unclear. In this study, we observed that most long noncoding RNAs (lncRNAs) were either notably up- or downregulated in NSCLC cells after treatment with Aila. Moreover, alterations in lncRNA expression induced by Aila were crucial for the initiation and metastasis of NSCLC. Furthermore, in our research, expression of DUXAP8 was significantly downregulated in NSCLC cells after treatment with Aila and regulated expression levels of EGR1. In conclusion, our findings demonstrate that Aila is a potent natural suppressor of NSCLC by modulating expression of DUXAP8 and EGR1.
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spelling pubmed-82559212021-07-06 Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition Chen, Lin Wu, Cui Wang, Heming Chen, Sinuo Ma, Danhui Tao, Ye Wang, Xingye Luan, Yanhe Wang, Tiedong Shi, Yan Song, Guangqi Zhao, Yicheng Dong, Xijun Wang, Bingmei Front Oncol Oncology Non-small cell lung cancer (NSCLC) has the highest morbidity and mortality among all carcinomas. However, it is difficult to diagnose in the early stage, and current therapeutic efficacy is not ideal. Although numerous studies have revealed that Ailanthone (Aila), a natural product, can inhibit multiple cancers by reducing cell proliferation and invasion and inducing apoptosis, the mechanism by which Aila represses NSCLC progression in a time-dependent manner remains unclear. In this study, we observed that most long noncoding RNAs (lncRNAs) were either notably up- or downregulated in NSCLC cells after treatment with Aila. Moreover, alterations in lncRNA expression induced by Aila were crucial for the initiation and metastasis of NSCLC. Furthermore, in our research, expression of DUXAP8 was significantly downregulated in NSCLC cells after treatment with Aila and regulated expression levels of EGR1. In conclusion, our findings demonstrate that Aila is a potent natural suppressor of NSCLC by modulating expression of DUXAP8 and EGR1. Frontiers Media S.A. 2021-06-21 /pmc/articles/PMC8255921/ /pubmed/34235076 http://dx.doi.org/10.3389/fonc.2021.652567 Text en Copyright © 2021 Chen, Wu, Wang, Chen, Ma, Tao, Wang, Luan, Wang, Shi, Song, Zhao, Dong and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Lin
Wu, Cui
Wang, Heming
Chen, Sinuo
Ma, Danhui
Tao, Ye
Wang, Xingye
Luan, Yanhe
Wang, Tiedong
Shi, Yan
Song, Guangqi
Zhao, Yicheng
Dong, Xijun
Wang, Bingmei
Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition
title Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition
title_full Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition
title_fullStr Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition
title_full_unstemmed Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition
title_short Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition
title_sort analysis of long noncoding rnas in aila-induced non-small cell lung cancer inhibition
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255921/
https://www.ncbi.nlm.nih.gov/pubmed/34235076
http://dx.doi.org/10.3389/fonc.2021.652567
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