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Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction

BACKGROUND: Respiratory muscle unloading through proportional assist ventilation (PAV) may enhance leg oxygen delivery, thereby speeding off-exercise oxygen uptake ([Formula: see text]) kinetics in patients with heart failure with reduced left ventricular ejection fraction (HFrEF). METHODS: Ten male...

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Autores principales: Borghi-Silva, Audrey, Goulart, Cassia da Luz, Carrascosa, Cláudia R., Oliveira, Cristino Carneiro, Berton, Danilo C., de Almeida, Dirceu Rodrigues, Nery, Luiz Eduardo, Arena, Ross, Neder, J. Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255967/
https://www.ncbi.nlm.nih.gov/pubmed/34234692
http://dx.doi.org/10.3389/fphys.2021.685274
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author Borghi-Silva, Audrey
Goulart, Cassia da Luz
Carrascosa, Cláudia R.
Oliveira, Cristino Carneiro
Berton, Danilo C.
de Almeida, Dirceu Rodrigues
Nery, Luiz Eduardo
Arena, Ross
Neder, J. Alberto
author_facet Borghi-Silva, Audrey
Goulart, Cassia da Luz
Carrascosa, Cláudia R.
Oliveira, Cristino Carneiro
Berton, Danilo C.
de Almeida, Dirceu Rodrigues
Nery, Luiz Eduardo
Arena, Ross
Neder, J. Alberto
author_sort Borghi-Silva, Audrey
collection PubMed
description BACKGROUND: Respiratory muscle unloading through proportional assist ventilation (PAV) may enhance leg oxygen delivery, thereby speeding off-exercise oxygen uptake ([Formula: see text]) kinetics in patients with heart failure with reduced left ventricular ejection fraction (HFrEF). METHODS: Ten male patients (HFrEF = 26 ± 9%, age 50 ± 13 years, and body mass index 25 ± 3 kg m(2)) underwent two constant work rate tests at 80% peak of maximal cardiopulmonary exercise test to tolerance under PAV and sham ventilation. Post-exercise kinetics of [Formula: see text] , vastus lateralis deoxyhemoglobin ([deoxy-Hb + Mb]) by near-infrared spectroscopy, and cardiac output (Q(T)) by impedance cardiography were assessed. RESULTS: PAV prolonged exercise tolerance compared with sham (587 ± 390 s vs. 444 ± 296 s, respectively; p = 0.01). PAV significantly accelerated [Formula: see text] recovery (τ = 56 ± 22 s vs. 77 ± 42 s; p < 0.05), being associated with a faster decline in Δ[deoxy-Hb + Mb] and Q(T) compared with sham (τ = 31 ± 19 s vs. 42 ± 22 s and 39 ± 22 s vs. 78 ± 46 s, p < 0.05). Faster off-exercise decrease in Q(T) with PAV was related to longer exercise duration (r = −0.76; p < 0.05). CONCLUSION: PAV accelerates the recovery of central hemodynamics and muscle oxygenation in HFrEF. These beneficial effects might prove useful to improve the tolerance to repeated exercise during cardiac rehabilitation.
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spelling pubmed-82559672021-07-06 Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction Borghi-Silva, Audrey Goulart, Cassia da Luz Carrascosa, Cláudia R. Oliveira, Cristino Carneiro Berton, Danilo C. de Almeida, Dirceu Rodrigues Nery, Luiz Eduardo Arena, Ross Neder, J. Alberto Front Physiol Physiology BACKGROUND: Respiratory muscle unloading through proportional assist ventilation (PAV) may enhance leg oxygen delivery, thereby speeding off-exercise oxygen uptake ([Formula: see text]) kinetics in patients with heart failure with reduced left ventricular ejection fraction (HFrEF). METHODS: Ten male patients (HFrEF = 26 ± 9%, age 50 ± 13 years, and body mass index 25 ± 3 kg m(2)) underwent two constant work rate tests at 80% peak of maximal cardiopulmonary exercise test to tolerance under PAV and sham ventilation. Post-exercise kinetics of [Formula: see text] , vastus lateralis deoxyhemoglobin ([deoxy-Hb + Mb]) by near-infrared spectroscopy, and cardiac output (Q(T)) by impedance cardiography were assessed. RESULTS: PAV prolonged exercise tolerance compared with sham (587 ± 390 s vs. 444 ± 296 s, respectively; p = 0.01). PAV significantly accelerated [Formula: see text] recovery (τ = 56 ± 22 s vs. 77 ± 42 s; p < 0.05), being associated with a faster decline in Δ[deoxy-Hb + Mb] and Q(T) compared with sham (τ = 31 ± 19 s vs. 42 ± 22 s and 39 ± 22 s vs. 78 ± 46 s, p < 0.05). Faster off-exercise decrease in Q(T) with PAV was related to longer exercise duration (r = −0.76; p < 0.05). CONCLUSION: PAV accelerates the recovery of central hemodynamics and muscle oxygenation in HFrEF. These beneficial effects might prove useful to improve the tolerance to repeated exercise during cardiac rehabilitation. Frontiers Media S.A. 2021-06-21 /pmc/articles/PMC8255967/ /pubmed/34234692 http://dx.doi.org/10.3389/fphys.2021.685274 Text en Copyright © 2021 Borghi-Silva, Goulart, Carrascosa, Oliveira, Berton, de Almeida, Nery, Arena and Neder. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Borghi-Silva, Audrey
Goulart, Cassia da Luz
Carrascosa, Cláudia R.
Oliveira, Cristino Carneiro
Berton, Danilo C.
de Almeida, Dirceu Rodrigues
Nery, Luiz Eduardo
Arena, Ross
Neder, J. Alberto
Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction
title Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction
title_full Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction
title_fullStr Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction
title_full_unstemmed Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction
title_short Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction
title_sort proportional assist ventilation improves leg muscle reoxygenation after exercise in heart failure with reduced ejection fraction
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255967/
https://www.ncbi.nlm.nih.gov/pubmed/34234692
http://dx.doi.org/10.3389/fphys.2021.685274
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