Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing

High-acuity αβT cell receptor (TCR) recognition of peptides bound to major histocompatibility complex molecules (pMHCs) requires mechanosensing, a process whereby piconewton (pN) bioforces exert physical load on αβTCR–pMHC bonds to dynamically alter their lifetimes and foster digital sensitivity cel...

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Detalles Bibliográficos
Autores principales: Mallis, Robert J., Duke-Cohan, Jonathan S., Das, Dibyendu Kumar, Akitsu, Aoi, Luoma, Adrienne M., Banik, Debasis, Stephens, Hannah M., Tetteh, Paul W., Castro, Caitlin D., Krahnke, Sophie, Hussey, Rebecca E., Lawney, Brian, Brazin, Kristine N., Reche, Pedro A., Hwang, Wonmuk, Adams, Erin J., Lang, Matthew J., Reinherz, Ellis L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256041/
https://www.ncbi.nlm.nih.gov/pubmed/34172580
http://dx.doi.org/10.1073/pnas.2023050118

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