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Reconciliation of Two Cognitive Models in Obsessive-Compulsive Disorder: An fMRI Study

OBJECTIVE: Although cognitive models of obsessive-compulsive disorder (OCD) fall into two categories: cognitive deficit models and dysfunctional belief models, these approaches have their own ways and have hardly been reconciled. Therefore, this study aimed to investigate the potential relationships...

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Autores principales: Kim, Seungho, Lee, Sang Won, Cha, Hyunsil, Kim, Eunji, Chang, Yongmin, Lee, Seung Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256141/
https://www.ncbi.nlm.nih.gov/pubmed/34218642
http://dx.doi.org/10.30773/pi.2020.0347
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author Kim, Seungho
Lee, Sang Won
Cha, Hyunsil
Kim, Eunji
Chang, Yongmin
Lee, Seung Jae
author_facet Kim, Seungho
Lee, Sang Won
Cha, Hyunsil
Kim, Eunji
Chang, Yongmin
Lee, Seung Jae
author_sort Kim, Seungho
collection PubMed
description OBJECTIVE: Although cognitive models of obsessive-compulsive disorder (OCD) fall into two categories: cognitive deficit models and dysfunctional belief models, these approaches have their own ways and have hardly been reconciled. Therefore, this study aimed to investigate the potential relationships between cognitive deficit (using the Wisconsin Card Sorting Task, WCST) and dysfunctional belief (measured by scales of dysfunctional beliefs) mediated by neural activity in OCD patients. METHODS: Thirty OCD patients and 30 healthy participants performed the WCST condition and a baseline MATCH condition during the 3T-functional magnetic resonance imaging (fMRI) acquisition. RESULTS: Engagement of additional frontoparietal networks with poorer performance of WCST was found during the fMRI scan in OCD patients. Selected regions of interest from activated regions have positive relationships with dysfunctional beliefs and with the unacceptable thoughts symptom dimension in the OCD group. CONCLUSION: Findings suggest that alteration in frontoparietal networks related to cognitive deficits can be associated with dysfunctional beliefs while performing conventional neurocognitive tasks and this association with dysfunctional beliefs may be pronounced in the unacceptable thoughts domain-dominant OCD patients.
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spelling pubmed-82561412021-07-19 Reconciliation of Two Cognitive Models in Obsessive-Compulsive Disorder: An fMRI Study Kim, Seungho Lee, Sang Won Cha, Hyunsil Kim, Eunji Chang, Yongmin Lee, Seung Jae Psychiatry Investig Original Article OBJECTIVE: Although cognitive models of obsessive-compulsive disorder (OCD) fall into two categories: cognitive deficit models and dysfunctional belief models, these approaches have their own ways and have hardly been reconciled. Therefore, this study aimed to investigate the potential relationships between cognitive deficit (using the Wisconsin Card Sorting Task, WCST) and dysfunctional belief (measured by scales of dysfunctional beliefs) mediated by neural activity in OCD patients. METHODS: Thirty OCD patients and 30 healthy participants performed the WCST condition and a baseline MATCH condition during the 3T-functional magnetic resonance imaging (fMRI) acquisition. RESULTS: Engagement of additional frontoparietal networks with poorer performance of WCST was found during the fMRI scan in OCD patients. Selected regions of interest from activated regions have positive relationships with dysfunctional beliefs and with the unacceptable thoughts symptom dimension in the OCD group. CONCLUSION: Findings suggest that alteration in frontoparietal networks related to cognitive deficits can be associated with dysfunctional beliefs while performing conventional neurocognitive tasks and this association with dysfunctional beliefs may be pronounced in the unacceptable thoughts domain-dominant OCD patients. Korean Neuropsychiatric Association 2021-06 2021-06-24 /pmc/articles/PMC8256141/ /pubmed/34218642 http://dx.doi.org/10.30773/pi.2020.0347 Text en Copyright © 2021 Korean Neuropsychiatric Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Seungho
Lee, Sang Won
Cha, Hyunsil
Kim, Eunji
Chang, Yongmin
Lee, Seung Jae
Reconciliation of Two Cognitive Models in Obsessive-Compulsive Disorder: An fMRI Study
title Reconciliation of Two Cognitive Models in Obsessive-Compulsive Disorder: An fMRI Study
title_full Reconciliation of Two Cognitive Models in Obsessive-Compulsive Disorder: An fMRI Study
title_fullStr Reconciliation of Two Cognitive Models in Obsessive-Compulsive Disorder: An fMRI Study
title_full_unstemmed Reconciliation of Two Cognitive Models in Obsessive-Compulsive Disorder: An fMRI Study
title_short Reconciliation of Two Cognitive Models in Obsessive-Compulsive Disorder: An fMRI Study
title_sort reconciliation of two cognitive models in obsessive-compulsive disorder: an fmri study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256141/
https://www.ncbi.nlm.nih.gov/pubmed/34218642
http://dx.doi.org/10.30773/pi.2020.0347
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